ArticleVeterinary research2014
Neospora caninum infection as a cause of reproductive failure in a sheep flock.
Article in Veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The Global Prevalence ofFrontiers in veterinary science · 2022Pooled it
- Seroprevalence ofVeterinary sciences · 2026Article
- Nationwide enzooticity of ovine toxoplasmosis and neosporosis in Türkiye.BMC microbiology · 2025Article
- Anti-Neospora caninum and anti-Toxoplasma gondii antibodies in cattle intended for human consumption in the State of Espírito Santo, Brazil: prevalence and associated factors.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Article
- First report ofJournal of advanced veterinary and animal research · 2024Article
- Molecular Investigation of Small Ruminant Abortions Using a 10-Plex HRM-qPCR Technique: A Novel Approach in Routine Diagnostics.Microorganisms · 2024Article
- Recombinant Dense Granule Protein (NcGRA4) Is a Novel Serological Marker forAnimals : an open access journal from MDPI · 2023Article
- Article
- Ovine Neosporosis: The Current Global Situation.Animals : an open access journal from MDPI · 2022Review
- A survey on Apicomplexa protozoa in sheep slaughtered for human consumption.Parasitology research · 2022Article
- Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus).Parasitology research · 2022Article
- Molecular detection and identification of three intracellular parasites of retail mutton products in Beijing, China.Frontiers in veterinary science · 2022Article
- Dynamics ofPathogens (Basel, Switzerland) · 2021Article
- Neospora caninum is not an important contributor to poor reproductive performance of primiparous ewes from southern Australia: evidence from a cross-sectional study.Parasitology research · 2021Article
- One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.Veterinary parasitology · 2021Review
- Article
- Isolation and genetic characterization of Toxoplasma gondii in Spanish sheep flocks.Parasites & vectors · 2020Article
- Research intoPathogens (Basel, Switzerland) · 2020Review
- Molecular and histopathological identification of ovine neosporosis (Veterinary world · 2020Article
- Flea infestation, social contact, and stress in a gregarious rodent species: minimizing the potential parasitic costs of group-living.Parasitology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neospora caninum has been detected only sporadically in cases of ovine abortion, and it has therefore traditionally been considered as an unimportant parasite in small ruminants. This study was carried out with the aim of identifying the pathogen causing serious reproductive problems on a commercial sheep farm. Sera from all rams and ewes tested negative for antibodies against Border disease virus, Schmallenberg virus and Coxiella burnetii, and infections by these agents were therefore ruled out. Nevertheless, seropositivity to N. caninum and/or Toxoplasma gondii was detected, although the seroprevalence was higher in the case of N. caninum. The percentage of lambings and the number of lambs per dam were significantly lower in ewes that were seropositive to N. caninum while no effect on these parameters was detected in ewes that were seropositive to T. gondii. There was also no evidence of infection by T. gondii in the foetal/lamb tissues analyzed by PCR and/or immunohistopathological techniques. On the contrary, the DNA of N. caninum was detected in 13 out of 14 foetuses/lambs descendant from dams seropositive to this parasite. Characteristic lesions caused by N. caninum and/or its antigen were also detected. Genotyping of the N. caninum DNA revealed only two closely related microsatellite multilocus genotypes. The results clearly demonstrate that infection by N. caninum was the cause of the low reproductive performance of this sheep flock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.