ArticleConnective tissue research2014
Critical role of Bmpr1a in mandibular condyle growth.
Article in Connective tissue research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Augmented Bone Morphogenetic Protein Signaling During TMJ Development Alters Morphology in a Timepoint-Dependent Manner.International journal of molecular sciences · 2025Article
- Influence of bone morphogenetic protein (BMP) signaling and masticatory load on morphological alterations of the mouse mandible during postnatal development.Archives of oral biology · 2025Article
- Article
- BMP2 rs1005464 is associated with mandibular condyle size variation.Scientific reports · 2024Article
- Bone or Tooth dentin: The TGF-β signaling is the key.International journal of biological sciences · 2024Article
- Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-Enthesis.International journal of biological sciences · 2023Article
- [Latest Research Findings on the Regulation of Bone Homeostasis by ALK3].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection.Frontiers in physiology · 2022Review
- An ECHO of Cartilage:Frontiers in bioengineering and biotechnology · 2021Article
- ScxBone · 2021Article
- Article
- IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage.Biochemical and biophysical research communications · 2019Article
- Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.International journal of biological sciences · 2018Article
- Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process.Scientific reports · 2017Article
- Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair.Journal of dental research · 2017Review
- The biological function of type I receptors of bone morphogenetic protein in bone.Bone research · 2016Review
- Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth.Journal of dental research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The importance of Bone Morphogenetic Proteins (BMPs) in the regulation of cell fate, differentiation and proliferation in the growth plate is well-known. However, in secondary cartilages (such as that in the temporomandibular joint) that grow by proliferation of prechondrocytes and differ in their pattern of growth, the role of BMPs is largely unexplored. To examine this question, we ablated Bmpr1a in the condylar cartilage of neonatal mice and assessed the consequences for mandibular condyle growth and organization at intervals over the ensuing 4 weeks. Bmpr1a deficiency caused significant chondrodysplasia and almost eliminated the chondrocytic phenotype in the TMJ. Expression of Sox9, collagen II, proteoglycan were all greatly reduced, and cell proliferation as detected by BrdU was almost non-existent in the knockout mice. Primary bone spongiosa formation was also disturbed and was accompanied by reduced Osterix expression. These findings strongly suggest that Bmpr1a is critical for the development and growth of the mandibular condyle via its effect on proliferation of prechondroblasts and chondrocyte differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.