ArticlePloS one2014
A genome-wide association study reveals dominance effects on number of teats in pigs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-Wide Association Study Meta-Analysis Elucidates Genetic Structure and Identifies Candidate Genes of Teat Number Traits in Pigs.International journal of molecular sciences · 2023Pooled it
- Functional genomic dissection and prediction of body size traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Influence of genomic retained heterosis on lactation persistence and tropical resilience: leveraging joint-model GWAS to quantify non-additive variance in India's Karan Fries population.Tropical animal health and production · 2026Article
- Fine-Mapping-Based Variant Prioritization and Genomic Prediction Enhance Genetic Analyses of Teat Traits in Pigs.Animals : an open access journal from MDPI · 2026Article
- Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach.Current issues in molecular biology · 2026Article
- Genetic diversity and association analysis of the growth hormone gene in local Indonesian chicken.Journal of advanced veterinary and animal research · 2025Article
- Multiple association studies identify 3 novel candidate genes for teat number trait in Danish Landrace and Large White pigs: BRINP3, LIN52, and UBE3B.Journal of animal science · 2025Article
- Genome-wide detection of multiple variants associated with teat number in French Yorkshire pigs.BMC genomics · 2024Article
- Additive and Dominance Genome-Wide Association Studies Reveal the Genetic Basis of Heterosis Related to Growth Traits of Duhua Hybrid Pigs.Animals : an open access journal from MDPI · 2024Article
- Aluminium stress tolerance byPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations.Animals : an open access journal from MDPI · 2024Article
- Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.Genome biology · 2023Article
- Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs.Animals : an open access journal from MDPI · 2023Article
- Identification of the genetic basis of sow pelvic organ prolapse.Frontiers in genetics · 2023Article
- Insights into the architecture of human-induced polygenic selection in Duroc pigs.Journal of animal science and biotechnology · 2022Article
- Genomic evaluation and genome-wide association studies for total number of teats in a combined American and Danish Yorkshire pig populations selected in China.Journal of animal science · 2022Article
- Haplotype genomic prediction of phenotypic values based on chromosome distance and gene boundaries using low-coverage sequencing in Duroc pigs.Genetics, selection, evolution : GSE · 2021Article
- Single-marker and haplotype-based genome-wide association studies for the number of teats in two heavy pig breeds.Animal genetics · 2021Article
- Revealing New Candidate Genes for Teat Number Relevant Traits in Duroc Pigs Using Genome-Wide Association Studies.Animals : an open access journal from MDPI · 2021Article
- Genome-Wide Association Study for Body Length, Body Height, and Total Teat Number in Large White Pigs.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dominance has been suggested as one of the genetic mechanisms explaining heterosis. However, using traditional quantitative genetic methods it is difficult to obtain accurate estimates of dominance effects. With the availability of dense SNP (Single Nucleotide Polymorphism) panels, we now have new opportunities for the detection and use of dominance at individual loci. Thus, the aim of this study was to detect additive and dominance effects on number of teats (NT), specifically to investigate the importance of dominance in a Landrace-based population of pigs. In total, 1,550 animals, genotyped for 32,911 SNPs, were used in single SNP analysis. SNPs with a significant genetic effect were tested for their mode of gene action being additive, dominant or a combination. In total, 21 SNPs were associated with NT, located in three regions with additive (SSC6, 7 and 12) and one region with dominant effects (SSC4). Estimates of additive effects ranged from 0.24 to 0.29 teats. The dominance effect of the QTL located on SSC4 was negative (-0.26 teats). The additive variance of the four QTLs together explained 7.37% of the total phenotypic variance. The dominance variance of the four QTLs together explained 1.82% of the total phenotypic variance, which corresponds to one-fourth of the variance explained by additive effects. The results suggest that dominance effects play a relevant role in the genetic architecture of NT. The QTL region on SSC7 contains the most promising candidate gene: VRTN. This gene has been suggested to be related to the number of vertebrae, a trait correlated with NT.
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