ArticleJournal of the American Chemical Society2014
Mitochondria-immobilized pH-sensitive off-on fluorescent probe.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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Who cites it
69 citing papers in PubMed.
- Lipid Droplet Specific Targeted Polarity-Sensitive NIR Fluorescence Carbon Dots for Imaging Metabolic Dysfunction-Associated Steatotic Liver Disease.Chemical & biomedical imaging · 2026Article
- Pmpcb modulates zebrafish neurogenesis and stress resistance via regulating mitochondria metabolism and function.Molecular neurobiology · 2026Article
- NADH-Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A multifunctional AIE probe with dual organelle targeting and without crosstalk for the simultaneous detection of SOMikrochimica acta · 2025Article
- Real-Time Monitoring of Mitochondrial pH in HeLa Cells,ACS applied bio materials · 2025Article
- Rhodamine-derived ratiometric fluorescent probes for high-sensitivity detection and real-time imaging of mitochondrial pH and viscosity in HeLa cells andJournal of materials chemistry. B · 2025Article
- Betulinic Acid ω-Triphenylphosphonium Alkyl Esters: Antiproliferative Activities and In Silico Pharmacokinetic Profiles.Biomedicines · 2025Article
- Introducing TAPY as a Versatile Alternative to TPP for Selective Mitochondrial Targeting in Cancer Cells.Bioconjugate chemistry · 2025Article
- Signal-Sustained Imaging of Mitophagy with an Enzyme-Activatable Metabolic Lipid Labeling Probe.Autophagy · 2024Article
- Article
- Near-Infrared Fluorescent Probe with pH- and Viscosity-Switchable Performance for the Detection of Thrombi in Live Animals and Organs.Chemical & biomedical imaging · 2024Article
- SERS-based long-term mitochondrial pH monitoring during differentiation of human induced pluripotent stem cells to neural progenitor cells.Biomedical optics express · 2024Article
- Non-destructive real-time monitoring and investigation of the self-assembly process using fluorescent probes.Chemical science · 2024Review
- Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging.Nature communications · 2024Article
- Advances in Small-Molecule Fluorescent pH Probes for Monitoring Mitophagy.Chemical & biomedical imaging · 2024Review
- Review
- Mitochondrial proton leak in cardiac aging.GeroScience · 2023Review
- Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker.Autophagy · 2023Article
- Organic Fluorescent Probes for Monitoring Micro-Environments in Living Cells and Tissues.Molecules (Basel, Switzerland) · 2023Review
- Near-infrared rhodol dyes bearing salicylaldehyde moieties for ratiometric pH sensing in live cells during mitophagy and under hypoxia conditions.Journal of materials chemistry. B · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We report here a mitochondria-targetable pH-sensitive probe that allows for a quantitative measurement of mitochondrial pH changes, as well as the real-time monitoring of pH-related physiological effects in live cells. This system consists of a piperazine-linked naphthalimide as a fluorescence off-on signaling unit, a cationic triphenylphosphonium group for mitochondrial targeting, and a reactive benzyl chloride subunit for mitochondrial fixation. It operates well in a mitochondrial environment within whole cells and displays a desirable off-on fluorescence response to mitochondrial acidification. Moreover, this probe allows for the monitoring of impaired mitochondria undergoing mitophagic elimination as the result of nutrient starvation. It thus allows for the monitoring of the organelle-specific dynamics associated with the conversion between physiological and pathological states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.