ReviewStem cell research & therapy2014
Ovarian germline stem cells.
Review in Stem cell research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Advances in porcine stem cell research and their applications in agriculture.Frontiers in cell and developmental biology · 2026Review
- In Vitro Gamete Production in Mammals: Decades of Pioneering Approaches in Germ Cell and Stem Cell Biology Supporting Innovative Discovery and Expansion of Human Reproductive Potential.Molecular reproduction and development · 2025Review
- Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors.Journal of ovarian research · 2023Article
- Characterization of the In Vitro Cultured Ovarian Cells in the Asian Yellow Pond Turtle (Biology · 2022Article
- Telomeres and Telomerase in the Control of Stem Cells.Biomedicines · 2022Review
- Article
- Female germline stem cells: aging and anti-aging.Journal of ovarian research · 2022Review
- Parental age at conception on mouse lemur's offspring longevity: Sex-specific maternal effects.PloS one · 2022Article
- Article
- Microplastics and Their Impact on Reproduction-Can we Learn From theFrontiers in toxicology · 2022Review
- Article
- Germline Stem Cells in Myocardial Regeneration - A new hope worth a delve.Journal of stem cells & regenerative medicine · 2018Article
- Differentiation of Mouse Primordial Germ Cells into Functional Oocytes In Vitro.Annals of biomedical engineering · 2017Review
- Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway.Cell death & disease · 2017Article
- Mutation rates and the evolution of germline structure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Molecular insights into the aetiology of female reproductive ageing.Nature reviews. Endocrinology · 2015Review
- Oogonial stem cells as a model to study age-associated infertility in women.Reproduction, fertility, and development · 2015Review
- The ability of mouse nuclear transfer embryonic stem cells to differentiate into primordial germ cells.Genetics and molecular biology · 2015Article
- Stem cells in genitourinary regeneration.Stem cell research & therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
It has long been established that germline stem cells (GSCs) are responsible for lifelong gametogenesis in males, and some female invertebrates (for example, Drosophila) and lower vertebrates (for example, teleost fish and some prosimians) also appear to rely on GSCs to replenish their oocyte reserve in adulthood. However, the presence of such cells in the majority of female mammals is controversial, and the idea of a fixed ovarian reserve determined at birth is the prevailing belief among reproductive biologists. However, accumulating evidence demonstrates the isolation and culture of putative GSCs from the ovaries of adult mice and humans. Live offspring have been reportedly produced from the culture of adult mouse GSCs, and human GSCs formed primordial follicles using a mouse xenograft model. If GSCs were present in adult female ovaries, it could be postulated that the occurrence of menopause is not due to the exhaustion of a fixed supply of oocytes but instead is a result of GSC and somatic cell aging. Alternatively, they may be benign under normal physiological conditions. If their existence were confirmed, female GSCs could have many potential applications in both basic science and clinical therapies. GSCs not only may provide a valuable model for germ cell development and maturation but may have a role in the field of fertility preservation, with women potentially being able to store GSCs or GSC-derived oocytes from their own ovaries prior to infertility-inducing treatments. Essential future work in this field will include further independent corroboration of the existence of GSCs in female mammals and the demonstration of the production of mature competent oocytes from GSCs cultured entirely in vitro.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.