ArticleAnatomy and embryology1989
The effect of fluoride on the patterns of adherence of osteoclasts cultured on and resorbing dentine: a 3-D assessment of vinculin-labelled cells using confocal optical microscopy.
Article in Anatomy and embryology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Histomorphometric and Histopathologic Evaluation of the Effects of Systemic Fluoride Intake on Orthodontic Tooth Movement.European journal of dentistry · 2019Article
- Time-lapse reveals that osteoclasts can move across the bone surface while resorbing.Journal of cell science · 2017Article
- Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss.International journal of oral science · 2015Article
- Fluoride's effects on the formation of teeth and bones, and the influence of genetics.Journal of dental research · 2011Review
- Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts.The Journal of biological chemistry · 2010Article
- Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption.BMC cell biology · 2004Article
- Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.The Journal of cell biology · 2000Article
- The cytoskeletal framework of chick osteoclasts in resin-less sections.Journal of anatomy · 1994Article
- Pitfalls in pit measurement.Calcified tissue international · 1991Article
- Echistatin is a potent inhibitor of bone resorption in culture.The Journal of cell biology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoclasts were isolated mechanically from chick long bones and cultured on dentine for three days in MEM/10% FCS with or without 1 mg/l NaF, (near to therapeutic ranges for serum fluoride levels) or 15 mg/l NaF (which has been found to reduce the volume:plan-area ratios of resorption pits in vitro). The distribution of close contacts with the substratum was determined by immunolabelling of vinculin and confocal fluorescence microscopy. Four characteristic patterns of contacts were observed: infilled discs, rings, crescents and patches: these reflect the progress of the cell in the process of pit formation. Cell-substratum adherence was more extensive than previously reported with contacts often extending down the sides of pits and sometimes across the floor. This distribution explains the curved shape of unilocular pits and the kidney-shaped extensions of multilocular pits. The peripheral creeping of the contact region was more marked in the osteoclasts of the 15 mg/l NaF cultures, and these cultures showed a decrease in pit depth and inhibition of osteoclastic movement in the presence of fluoride.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.