ArticleMolecular endocrinology (Baltimore, Md.)2014
Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice.
Article in Molecular endocrinology (Baltimore, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Testosterone and Obesity in an Aging Society.Biomolecules · 2025Review
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess.Endocrinology · 2025Article
- Androgen Inhibition of Reproductive Neuroendocrine Function in Females and Transgender Males.Endocrinology · 2024Review
- Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT.Endocrinology · 2024Article
- Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape.Frontiers in endocrinology · 2023Article
- Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.Biology of sex differences · 2022Article
- Comparison of Reproductive Function Between Normal and Hyperandrogenemia Conditions in Female Mice With Deletion of Hepatic Androgen Receptor.Frontiers in endocrinology · 2022Article
- Lower FSH With Normal Fertility in Male Mice Lacking Gonadotroph Kisspeptin Receptor.Frontiers in physiology · 2022Article
- Practical Approach to Hyperandrogenism in Women.The Medical clinics of North America · 2021Review
- Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.Molecular and cellular endocrinology · 2021Article
- Androgen-induced epigenetic modulations in the ovary.The Journal of endocrinology · 2021Review
- Androgens regulate ovarian gene expression by balancing Ezh2-Jmjd3 mediated H3K27me3 dynamics.PLoS genetics · 2021Article
- Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus.Reproductive biology and endocrinology : RB&E · 2020Article
- Lack of AR in LepRb Cells Disrupts Ambulatory Activity and Neuroendocrine Axes in a Sex-Specific Manner in Mice.Endocrinology · 2020Article
- Ovarian Androgens Maintain High GnRH Neuron Firing Rate in Adult Prenatally-Androgenized Female Mice.Endocrinology · 2020Article
- Gonadotrope androgen receptor mediates pituitary responsiveness to hormones and androgen-induced subfertility.JCI insight · 2019Article
- Mechanism of cadmium poisoning on testicular injury in mice.Oncology letters · 2019Article
- A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome.Journal of visualized experiments : JoVE · 2018Article
- Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.Endocrinology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Polycystic ovary syndrome is the major cause of infertility in reproductive aged women. Polycystic ovary syndrome is associated with high circulating levels of androgens and impaired metabolic function. The goal of this study was to understand how androgen signaling via the androgen receptor (AR) affects reproductive function. We knocked out the AR gene specifically in pituitary gonadotropes (PitARKO) to explore the role of androgen on the development of reproductive function in female mice. There was no difference in the age of puberty between control and PitARKO littermates, which was assessed by the ages of vaginal opening and first estrus. Cyclicity and fertility were also studied, and there was no significant difference between control and PitARKO mice. We observed a significant decrease in basal FSH serum and mRNA levels with no corresponding change in LH serum and mRNA levels. Although the numbers of litters born to control and PitARKO females were the same, the litter size was significantly smaller for PitARKO mice. The LH and FSH responses to ovariectomy was altered with reduced LH/FSH hormone and mRNA levels in PitARKO females. This reduction may be due to reduced expression of activin A/B and gnrhr. The preovulatory surge levels of LH and FSH were dramatically lower in PitARKO mice. The number of corpora lutea was decreased whereas the number of antral follicles was similar between control and PitARKO mice. Overall the pituitary AR contributes to the elaboration of the LH surge and normal reproductive function by regulating LH/FSH expression and secretion.
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