ArticlePloS one2014
An exploration of evolution, maturation, expression and function relationships in mir-23 ∼ 27 ∼ 24 cluster.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- An atlas of small non-coding RNAs in human preimplantation development.Nature communications · 2024Article
- Elucidation of how the Mir-23-27-24 cluster regulates development and aging.Experimental & molecular medicine · 2024Review
- RCOR1 is targeted by miR-23b-3p to modulate growth, colony formation, migration, and invasion of prostate cancer cells.International journal of clinical and experimental pathology · 2024Article
- Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous.Life (Basel, Switzerland) · 2023Article
- Review
- Article
- MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis.Reproductive biology and endocrinology : RB&E · 2019Review
- MicroRNA-27a (miR-27a) in Solid Tumors: A Review Based on Mechanisms and Clinical Observations.Frontiers in oncology · 2019Review
- A three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes.Molecular oncology · 2017Article
- Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.Blood · 2017Article
- MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation.Scientific reports · 2017Article
- A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.Scientific reports · 2017Article
- MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status.Oncotarget · 2017Article
- Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia.Oncology letters · 2016Article
- The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b.Molecular therapy. Nucleic acids · 2016Article
- miR-23∼27∼24 clusters control effector T cell differentiation and function.The Journal of experimental medicine · 2016Article
- miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer.Infectious agents and cancer · 2015Article
- Differential Expression of microRNAs in Thymic Epithelial Cells from Trypanosoma cruzi Acutely Infected Mice: Putative Role in Thymic Atrophy.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aims to explore the potential relationships of evolution, maturation, expression and function between homologous/clustered miRNAs. mir-23 ∼ 27 ∼ 24 gene cluster, including the two gene clusters (mir-23a and mir-23b) and the three miRNA gene families (mir-23, mir-27 and mir-24), was typically selected as an example. These related miRNAs show similar evolutionary patterns and various expression patterns. Most of them show consistent isomiR expression pattern, and the "switching" phenomenon can be found between different abundant isomiR species. These findings suggest that these sequence or location related miRNAs show the similar miRNA processing and maturation processes, and the robust selection of the most dominant isomiR exists in specific tissues. Functional analysis show that these miRNAs show similar distributions of enriched gene categories, suggesting the close functional prelateships via direct or indirect coordinate regulation in biological processes. The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.