Evidence map›Paper›PMID 25157508›Full record

ArticleNature neuroscience2014

CLEARance wars: PolyQ strikes back.

X William Yang, Ai Yamamoto

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

X William YangDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Ai YamamotoDepartments of Neurology, Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Columbia University · USNeurobehavioral Systems · US

Funding

Modulating selective autophagy to modify Huntington's diseaseR01NS077111 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ai Yamamoto · 2012 to 2026
$4.3M
Autophagy and NeurodegenerationR01NS063973 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MELIA, THOMAS JAMES, YAMAMOTO, AI · 2008 to 2019
$3.8M
NINDS NIH HHS R01 NS063973NINDS NIH HHS R01 NS077111
6 · The paper itself

Abstract

Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.

Indexed as

AnimalsAutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsFemaleHumansMaleMuscular Disorders, AtrophicPeptidesReceptors, AndrogenAR protein, humanBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPeptidespolyglutamineReceptors, AndrogenTcfeb protein, mouseTFEB protein, human

Identifiers

PMID25157508
OpenAlexW1981430724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.