ArticleAnalytical chemistry2014
Near-infrared silver cluster optically signaling oligonucleotide hybridization and assembling two DNA hosts.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Structure and luminescence of DNA-templated silver clusters.Nanoscale advances · 2021Review
- The spatial organization of trace silver atoms on a DNA template.RSC advances · 2020Review
- Switchable Dual-Emissive DNA-Stabilized Silver Nanoclusters.ACS omega · 2019Article
- Article
- Excited-State Relaxation and Förster Resonance Energy Transfer in an Organic Fluorophore/Silver Nanocluster Dyad.ACS omega · 2017Article
- A Segregated, Partially Oxidized, and Compact Ag10 Cluster within an Encapsulating DNA Host.Journal of the American Chemical Society · 2016Article
- DNA-Protected Silver Clusters for Nanophotonics.Nanomaterials (Basel, Switzerland) · 2015Review
- DNA-Directed Fluorescence Switching of Silver Clusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Silver clusters with ~10 atoms form within DNA strands, and the conjugates are chemical sensors. The DNA host hybridizes with short oligonucleotides, and the cluster moieties optically respond to these analytes. Our studies focus on how the cluster adducts perturb the structure of their DNA hosts. Our sensor is comprised of an oligonucleotide with two components: a 5'-cluster domain that complexes silver clusters and a 3'-recognition site that hybridizes with a target oligonucleotide. The single-stranded sensor encapsulates an ~11 silver atom cluster with violet absorption at 400 nm and with minimal emission. The recognition site hybridizes with complementary oligonucleotides, and the violet cluster converts to an emissive near-infrared cluster with absorption at 730 nm. Our key finding is that the near-infrared cluster coordinates two of its hybridized hosts. The resulting tertiary structure was investigated using intermolecular and intramolecular variants of the same dimer. The intermolecular dimer assembles in concentrated (~5 μM) DNA solutions. Strand stoichiometries and orientations were chromatographically determined using thymine-modified complements that increase the overall conjugate size. The intramolecular dimer develops within a DNA scaffold that is founded on three linked duplexes. The high local cluster concentrations and relative strand arrangements again favor the antiparallel dimer for the near-infrared cluster. When the two monomeric DNA/violet cluster conjugates transform to one dimeric DNA/near-infrared conjugate, the DNA strands accumulate silver. We propose that these correlated changes in DNA structure and silver stoichiometry underlie the violet to near-infrared cluster transformation.
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