ArticleMolecules (Basel, Switzerland)2014
Effect of chlorogenic acid on melanogenesis of B16 melanoma cells.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials.Nutrients · 2024Pooled it
- Elucidating the role of medicinal plants in melanoma treatment: a review on metastatic progression and phytochemical intervention.Frontiers in pharmacology · 2026Review
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- Preliminary Analysis of Bilberry NaDES Extracts as Versatile Active Ingredients of Natural Dermocosmetic Products: In Vitro Evaluation of Anti-Tyrosinase, Anti-Hyaluronidase, Anti-Collagenase, and UV Protective Properties.Plants (Basel, Switzerland) · 2025Article
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- Evaluation of Cytotoxic Activity of Cell Biomass fromMolecules (Basel, Switzerland) · 2024Article
- Fast Screening of Tyrosinase Inhibitors inMolecules (Basel, Switzerland) · 2024Article
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- A Systematic Study of Yiqi Qubai Standard Decoction for Treating Vitiligo Based on UPLC-Q-TOF/MS Combined with Chemometrics, Molecular Docking, and Cellular and Zebrafish Assays.Pharmaceuticals (Basel, Switzerland) · 2023Article
- In Vitro and In Vivo Anti-Aging Effect of Coffee Berry Nanoliposomes.Molecules (Basel, Switzerland) · 2023Article
- Phenolic acids and a static magnetic field change the expression of transforming growth factor β isoforms in amelanotic melanoma cells.Molecular biology reports · 2023Article
- Adding New Scientific Evidences on the Pharmaceutical Properties ofPlants (Basel, Switzerland) · 2023Article
- Screening and Evaluation of Dermo-Cosmetic Activities of the Invasive Plant SpeciesPlants (Basel, Switzerland) · 2022Article
- Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts.International journal of molecular sciences · 2022Article
- Novel Perceptions on Chemical Profile and Biopharmaceutical Properties ofPlants (Basel, Switzerland) · 2022Article
- Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects.Drug delivery · 2021Article
- Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol.Pharmaceuticals (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorogenic acid (CGA), the ester formed between caffeic acid and l-quinic acid, is a widespread phenolic compound. It is part of the human diet, found in foods such as coffee, apples, pears, etc. CGA is also was widely used in cosmetics, but the effects of CGA on melanogenesis are unknown. In this study, we analyzed the effects of CGA on cell proliferation, melanin content and tyrosinase of B16 murine melanoma cells. Additionally, the enzymatic reactions of CGA in B16 melanoma cells lytic solution were detected by UV spectrophotometry. Results showed CGA at 30 and 60 μM significantly suppresses cell proliferation. 8-MOP at 100 μM significantly promotes cell proliferation, but CGA can counter this. Incubated for 24 h, CGA (500 μM) improves melanogenesis while suppressing tyrosinase activity in B16 melanoma cells or 8-methoxypsoralen (8-MOP) co-incubated B16 melanoma cells. After 12 h, B16 melanoma cell treatment with CGA leads to an increase in melanin accumulation, however, after 48 h there is a decrease in melanin production which correlates broadly with a decrease in tyrosinase activity. CGA incubated with lytic solution 24 h turned brown at 37 °C. The formation of new products (with a maximum absorption at 295 nm) is associated with reduction of CGA (maximum absorption at 326 nm). Therefore, CGA has its two sidesroles in melanogenesis of B16 melanoma cells. CGA is a likely a substrate of melanin, but the metabolic product(s) of CGA may suppress melanogenesis in B16 melanoma cells by inhibiting tyrosinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.