ArticlePloS one2014
Notch inhibits Yorkie activity in Drosophila wing discs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Regulation of Hippo signaling by Atrophin in the developing Drosophila wing.Development (Cambridge, England) · 2026Article
- Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.Development (Cambridge, England) · 2023Article
- Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.bioRxiv : the preprint server for biology · 2023Article
- Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.Experimental dermatology · 2022Review
- Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.Cell death & disease · 2022Article
- The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.PLoS biology · 2019Article
- Hippo signalling during development.Development (Cambridge, England) · 2019Review
- The dynamics of Hippo signaling duringDevelopment (Cambridge, England) · 2018Article
- The apical scaffold big bang binds to spectrins and regulates the growth ofThe Journal of cell biology · 2018Article
- Article
- A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.Molecular cancer research : MCR · 2017Article
- Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.PLoS genetics · 2017Article
- Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development.G3 (Bethesda, Md.) · 2017Article
- Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.EMBO reports · 2017Article
- From vestigial to vestigial-like: the Drosophila gene that has taken wing.Development genes and evolution · 2016Review
- Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway.Molecular cancer research : MCR · 2016Review
- Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest.Development (Cambridge, England) · 2015Article
- Loss of putzig Activity Results in Apoptosis during Wing Imaginal Development in Drosophila.PloS one · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki), the Salvador/Warts/Hippo (SWH) pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd) is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg). We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.
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Registered trials
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