Evidence map›Paper›PMID 25157365›Full record

ArticleBioMed research international2014

Epithelial-mesenchymal transition and somatic alteration in colorectal cancer with and without peritoneal carcinomatosis.

Y A Shelygin, N I Pospekhova, V P Shubin, V N Kashnikov, S A Frolov, O I Sushkov, S I Achkasov, A S Tsukanov

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Colorectal peritoneal metastases: Optimal management review.World journal of gastroenterology · 2019
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Y A ShelyginState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
N I PospekhovaState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
V P ShubinState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
V N KashnikovState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
S A FrolovState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
O I SushkovState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
S I AchkasovState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
A S TsukanovState Scientific Centre of Coloproctology, 2 Salyam Adil Street, Moscow 123423, Russia.
State Scientific Center of Coloproctology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is highly metastatic even when the tumors are small. To disseminate, cells use a complex and multistage process known as the epithelial-mesenchymal transition, in which epithelial phenotype is transformed into mesenchymal phenotype. The objective of this study is to describe the epithelial-mesenchymal transition in terms of gene expression profile and somatic alterations in samples of colorectal cancer with or without peritoneal carcinomatosis. We analyzed samples taken from 38 patients with colorectal cancer (stages II-IV) and samples from 20 patients with colorectal cancer complicated by peritoneal carcinomatosis. The expression of ZEB1, ZEB2, CDH1, VIM, and SNAI1 was analyzed by real-time PCR. KRAS/BRAF mutations were mapped using sequencing. Microsatellite instability was evaluated by fragment analysis. Epithelial-mesenchymal transition was detected in 6 out of 38 samples of colorectal cancer (stages II-IV), 7 out of 20 tumors from patients with peritoneal carcinomatosis, and 19 out of 20 samples taken from carcinomatous nodules. Tumors of the mesenchymal subtype displayed high frequency of somatic mutations, microsatellite stability, and low degree of differentiation. The identification of epithelial-mesenchymal transition may be used as a marker of high metastatic potential, which is particularly relevant at early stages of tumor growth.

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMaleMicrosatellite InstabilityMiddle AgedMutationMutation RateNeoplasm StagingPeritoneal NeoplasmsProto-Oncogene ProteinsBRAF protein, humanKRAS protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)ras Proteins

Identifiers

PMID25157365
PMCPMC4137488
OpenAlexW2056392849

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.