Evidence map›Paper›PMID 25157350›Full record

ReviewBioMed research international2014

Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.

Cornelia Tolg, James B McCarthy, Arjang Yazdani, Eva A Turley

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 125 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Cornelia TolgLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A 790 Commissioners Road East, London, ON, Canada N6A 4L6.
James B McCarthyDepartment of Laboratory Medicine and Pathology, Masonic Comprehensive Cancer Center, Minneapolis, MN 55455, USA.
Arjang YazdaniLondon, ON, Canada N6A 4V2 Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, ON, Canada N6A 4V2.
Eva A TurleyLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A 790 Commissioners Road East, London, ON, Canada N6A 4L6 ; London, ON, Canada N6A 4V2 Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, ON, Canada N6A 4V2.
London Health Sciences Centre · CAUNC Lineberger Comprehensive Cancer CenterWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation. Whereas these changes are transient in repairing wounds, tumors do not regain tissue architecture but rather their continued progression is fueled in part by loss of normal tissue structure. As a result tumors are often described as wounds that do not heal. The ECM component hyaluronan (HA) and its receptor RHAMM have both been implicated in wound repair and tumor progression. This review highlights the similarities and differences in their roles during these processes and proposes that RHAMM-regulated wound repair functions may contribute to "cancerization" of the tumor microenvironment.

Indexed as

Wound HealingAnimalsCarcinogenesisExtracellular Matrix ProteinsHumansHyaluronan ReceptorsHyaluronic AcidSignal TransductionStromal CellsExtracellular Matrix Proteinshyaluronan-mediated motility receptorHyaluronan ReceptorsHyaluronic Acid

Identifiers

PMID25157350
PMCPMC4137499
OpenAlexW2053153875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.