ReviewFrontiers in aging neuroscience2014
The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle.
Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03477721 (The Role of the Muscle-nervous System Interface in Cancer Cachexia), which is not on this map. Cited by 216 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Muscle-nervous System Interface in Cancer Cachexia
Who cites it
216 citing papers in PubMed, 6 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Periocular motor neurotization: a systematic review of techniques and outcomes in orbicularis oculi reinnervation.Frontiers in ophthalmology · 2025Pooled it
- Mind-body training outperforms other physical activities in reducing frailty and enhancing quality of life in older adults: a network meta-analysis.Frontiers in public health · 2025Pooled it
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients.Frontiers in nutrition · 2022Pooled it
- The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- AChRs Degeneration at NMJ in Aging-Associated Sarcopenia-A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- MitoQ supplementation does not impact redox responses to acute exercise in skeletal muscle of older individuals.Redox biology · 2025Trial
- Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function.Journal of cachexia, sarcopenia and muscle · 2023Trial
- Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.GeroScience · 2021Trial
- From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging.Aging cell · 2026Review
- Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm.Communications biology · 2026Article
- Muscle-Specific Kinase Signaling and Its Therapeutic Potential.Muscle & nerve · 2026Review
- Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.The Journal of clinical investigation · 2026Article
- Skeletal Muscle Function Deficit Longitudinal Associations With Inflammation and Caloric Intake in Elderly. The InCHIANTI Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
- The Motor Neuromuscular Axis: The Overlooked Element of Developmental Programming in Diabetes and Metabolic Syndrome.International journal of molecular sciences · 2026Review
- Dietary diversity, multidimensional gait characteristics, and related biomarkers in older adults: a wearable sensors study.The journal of nutrition, health & aging · 2026Article
- Speech as a dynamic biomarker of physical aging: a longitudinal study.GeroScience · 2026Article
- Assessing the Recovery of Muscle Fatigue Using Shear Wave Elastography.Sports medicine - open · 2026Article
- Observational
156 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aging is associated with a progressive loss of muscle mass and strength and a decline in neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in musculoskeletal impairment that occurs with aging. However, whether changes in the NMJ precede or follow the decline of muscle mass and strength remains unresolved. Many factors such as mitochondrial dysfunction, oxidative stress, inflammation, changes in the innervation of muscle fibers, and mechanical properties of the motor units probably perform an important role in NMJ degeneration and muscle mass and strength decline in late life. This review addresses the primary events that might lead to NMJ dysfunction with aging, including studies on biomarkers, signaling pathways, and animal models. Interventions such as caloric restriction and exercise may positively affect the NMJ through this mechanism and attenuate the age-related progressive impairment in motor function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.