ArticleFrontiers in cellular neuroscience2014
Ovarian cycle-linked plasticity of δ-GABAA receptor subunits in hippocampal interneurons affects γ oscillations in vivo.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Efficacy comparison of different external traditional Chinese medicine therapies as monotherapy or in combination for premenstrual syndrome: a systematic review and network meta-analysis.Frontiers in psychiatry · 2026Pooled it
- A Role for δ Subunit-Containing GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Attention-deficit/hyperactivity disorder and the menstrual cycle: Theory and evidence.Hormones and behavior · 2024Review
- On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior.Frontiers in neuroscience · 2024Review
- Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Capturing the power of seizures: an empirical mode decomposition analysis of epileptic activity in the mouse hippocampus.Frontiers in molecular neuroscience · 2023Article
- Prefrontal GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus.Nature communications · 2022Article
- Physiological markers of rapid antidepressant effects of allopregnanolone.Journal of neuroendocrinology · 2022Review
- GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan.Frontiers in behavioral neuroscience · 2022Review
- Crosstalk Between GABAergic Neurotransmission and Inflammatory Cascades in the Post-ischemic Brain: Relevance for Stroke Recovery.Frontiers in cellular neuroscience · 2022Review
- Altered brain rhythms and behaviour in the accelerated ovarian failure mouse model of human menopause.Brain communications · 2022Article
- Article
- Melatonin for premenstrual syndrome: A potential remedy but not ready.Frontiers in endocrinology · 2022Review
- A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention.Aging · 2020Article
- Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity.Annals of the New York Academy of Sciences · 2020Article
- General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.Neuropharmacology · 2019Article
- Effect of estrous cycle on schizophrenia-like behaviors in MAM exposed rats.Behavioural brain research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
GABAA receptors containing δ subunits (δ-GABAARs) are GABA-gated ion channels with extra- and perisynaptic localization, strong sensitivity to neurosteroids (NS), and a high degree of plasticity. In selective brain regions they are expressed on specific principal cells and interneurons (INs), and generate a tonic conductance that controls neuronal excitability and oscillations. Plasticity of δ-GABAARs in principal cells has been described during states of altered NS synthesis including acute stress, puberty, ovarian cycle, pregnancy and the postpartum period, with direct consequences on neuronal excitability and network dynamics. The defining network events implicated in cognitive function, memory formation and encoding are γ oscillations (30-120 Hz), a well-timed loop of excitation and inhibition between principal cells and PV-expressing INs (PV + INs). The δ-GABAARs of INs can modify γ oscillations, and a lower expression of δ-GABAARs on INs during pregnancy alters γ frequency recorded in vitro. The ovarian cycle is another physiological event with large fluctuations in NS levels and δ-GABAARs. Stages of the cycle are paralleled by swings in memory performance, cognitive function, and mood in both humans and rodents. Here we show δ-GABAARs changes during the mouse ovarian cycle in hippocampal cell types, with enhanced expression during diestrus in principal cells and specific INs. The plasticity of δ-GABAARs on PV-INs decreases the magnitude of γ oscillations continuously recorded in area CA1 throughout several days in vivo during diestrus and increases it during estrus. Such recurring changes in γ magnitude were not observed in non-cycling wild-type (WT) females, cycling females lacking δ-GABAARs only on PV-INs (PV-Gabrd (-/-)), and in male mice during a time course equivalent to the ovarian cycle. Our findings may explain the impaired memory and cognitive performance experienced by women with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.