ReviewJournal of experimental neuroscience2013
Contributions of microglia to structural synaptic plasticity.
Review in Journal of experimental neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The Arp2/3 complex is required for in situ haptotactic response of microglia to iC3b.EMBO reports · 2026Article
- Physical confinement and phagocytic uptake induce persistent cell migration.Biology open · 2025Article
- The Arp2/3 complex is required forbioRxiv : the preprint server for biology · 2025Article
- Physical confinement and phagocytic uptake induce directional migration.bioRxiv : the preprint server for biology · 2025Article
- Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice.Frontiers in endocrinology · 2024Article
- Role of Microglia in Neuropathic Pain.Cureus · 2023Review
- Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure.Frontiers in aging neuroscience · 2022Article
- Effects of platelet-rich plasma on the memory impairment, apoptosis, and hippocampal synaptic plasticity in a rat model of hepatic encephalopathy.Brain and behavior · 2022Article
- Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage.Brain, behavior, and immunity · 2018Article
- The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death.Scientific reports · 2018Article
- The History, Status, Gaps, and Future Directions of Neurotoxicology in China.Environmental health perspectives · 2016Review
- Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures.Molecular autism · 2015Article
- Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.Translational psychiatry · 2014Article
- Mechanisms of cellular plasticity in cerebral perivascular region.Progress in brain researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity critically depends on reciprocal interactions between neurons and glia. Among glial cells, microglia represent approximately 10% of the total brain cell population serve as the brain's resident macrophage, and help to modulate neural activity. Because of their special role in the brain's immune response, microglia are involved in the pathological progression of neurodegenerative disorders such as Alzheimer's disease (AD). However, microglia also are surveyors of the brain's health and continuously contact dendritic spines to regulate structural synaptic changes. This review summarizes our current understanding of neuronal-microglial signals that affect neural function at the synapse. Here, we examine the role of microglia in neuronal synapses in pathological brains and specifically focus on in vivo studies using 2-photon microscopy. Furthermore, because the role of microglia in AD progression is controversial, we outline the interaction between neurons and microglia in pathological conditions such as AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.