Evidence map›Paper›PMID 25157113›Full record

ArticleEuropean heart journal2015

Nano-scale treatment for a macro-scale disease: nanoparticle-delivered siRNA silences CCR2 and treats myocarditis.

Leslie T Cooper, DeLisa Fairweather

Abstract readEditorialComment
In one paragraph

Article in European heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Leslie T CooperDivision of Cardiology, Mayo Clinic, Rochester, MN, USA cooper.leslie@mayo.edu.
DeLisa FairweatherJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Sex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6M
Autoimmune Determinants of Human Cardiac MyosinR56HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 2008 to 2015
$933k
Endocrine disruptors effect on inflammatory heart diseaseR21ES024414 · NIEHS · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2014 to 2015
$440k
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R56 HL056267NIEHS NIH HHS R21 ES024414
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAutoimmune DiseasesChemokine CCL2FemaleHumansMaleMyocarditisRNA, Small InterferingChemokine CCL2RNA, Small Interfering

Identifiers

PMID25157113
PMCPMC4465634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.