ArticleThe Journal of biological chemistry2014
Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluating Alkaline Phosphatase-Instructed Self-Assembly of d‑Peptide Diesters for Selectively Inhibiting Immunosuppressive Cancer Cells.ACS omega · 2026Article
- Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis.BMC cancer · 2025Article
- Peptide Assemblies for Cancer Therapy.ChemMedChem · 2023Review
- Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments.Science advances · 2022Article
- Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications.Chemical communications (Cambridge, England) · 2021Review
- Recent Progress in the Design and Medical Application of In Situ Self-Assembled Polypeptide Materials.Pharmaceutics · 2021Review
- Biomaterials based on noncovalent interactions of small molecules.EXCLI journal · 2020Review
- Down-regulating Proteolysis to Enhance Anticancer Activity of Peptide Nanofibers.Chemistry, an Asian journal · 2018Article
- Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-κB Targeting for Selective Necroptosis of Cancer Cells.Journal of the American Chemical Society · 2018Article
- Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives.Advanced healthcare materials · 2017Article
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Bioinspired assembly of small molecules in cell milieu.Chemical Society reviews · 2017Review
- In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells.Cell death & disease · 2017Article
- D-amino acid-containing supramolecular nanofibers for potential cancer therapeutics.Advanced drug delivery reviews · 2017Review
- Internal Structure and Preferential Protein Binding of Colloidal Aggregates.ACS chemical biology · 2017Article
- Engineering responsive supramolecular biomaterials: Toward smart therapeutics.Bioengineering & translational medicine · 2016Review
- Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells.Journal of the American Chemical Society · 2016Article
- Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.Chemical communications (Cambridge, England) · 2016Article
- Supramolecular biomaterials.Nature materials · 2016Review
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Emerging evidence reveals that prion-like structures play important roles to maintain the well-being of cells. Although self-assembly of small molecules also affords prion-like nanofibrils (PriSM), little is known about the functions and mechanisms of PriSM. Previous works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth of glioblastoma cells over neuronal cells and effectively inhibiting xenograft tumor in animal models. Here we examine the protein targets, the internalization, and the cytotoxicity pathway of the PriSM. The results show that the PriSM selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal filaments via promiscuous interactions with cytoskeletal proteins, thus inducing apoptosis. Intriguingly, Tau proteins are able to alleviate the effect of the PriSM, thus protecting neuronal cells. This work illustrates PriSM as a new paradigm for developing polypharmacological agents that promiscuously interact with multiple proteins yet result in a primary phenotype, such as cancer inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.