ArticleDiabetes2015
Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice.
Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Vertical Sleeve Gastrectomy Offers Protection against Disturbed Flow-Induced Atherosclerosis in High-Fat Diet-Fed Mice.International journal of molecular sciences · 2023Article
- Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.Annals of surgery · 2020Article
- Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats.Molecular metabolism · 2020Article
- Surgical Mouse Models of Vertical Sleeve Gastrectomy and Roux-en Y Gastric Bypass: a Review.Obesity surgery · 2019Review
- The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control.Endocrine reviews · 2019Review
- Article
- GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.Molecular metabolism · 2019Article
- Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition.Obesity surgery · 2019Article
- Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results.Obesity surgery · 2018Article
- Refinement of Perioperative Feeding in a Mouse Model of Vertical Sleeve Gastrectomy.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Apolipoprotein A-IV enhances cholecystokinnin secretion.Physiology & behavior · 2018Article
- Roux-en-Y gastric bypass reduces plasma cholesterol in diet-induced obese mice by affecting trans-intestinal cholesterol excretion and intestinal cholesterol absorption.International journal of obesity (2005) · 2018Article
- A Murine Model of Vertical Sleeve Gastrectomy.Journal of visualized experiments : JoVE · 2017Article
- Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study.Scientific reports · 2017Article
- Biliopancreatic Diversion Decreases Postprandial Apolipoprotein A-IV Levels in Mildly Obese Individuals with Type 2 Diabetes Mellitus: a Prospective Study.Obesity surgery · 2017Article
- Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.Molecular metabolism · 2017Article
- Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Article
- Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2016Article
- MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study.Diabetologia · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Bariatric surgery is the most successful strategy for treating obesity, yet the mechanisms for this success are not clearly understood. Clinical literature suggests that plasma levels of apolipoprotein A-IV (apoA-IV) rise with Roux-en-Y gastric bypass (RYGB). apoA-IV is secreted from the intestine postprandially and has demonstrated benefits for both glucose and lipid homeostasis. Because of the parallels in the metabolic improvements seen with surgery and the rise in apoA-IV levels, we hypothesized that apoA-IV was necessary for obtaining the metabolic benefits of bariatric surgery. To test this hypothesis, we performed vertical sleeve gastrectomy (VSG), a surgery with clinical efficacy very similar to that for RYGB, in whole-body apoA-IV knockout (KO) mice. We found that VSG reduced body mass and improved both glucose and lipid homeostasis similarly in wild-type mice compared with apoA-IV KO mice. In fact, VSG normalized the impairment in glucose tolerance and caused a significantly greater improvement in hepatic triglyceride storage in the apoA-IV KO mice. Last, independent of surgery, apoA-IV KO mice had a significantly reduced preference for a high-fat diet. Altogether, these data suggest that apoA-IV is not necessary for the metabolic improvements shown with VSG, but also suggest an interesting role for apoA-IV in regulating macronutrient preference and hepatic triglyceride levels. Future studies are necessary to determine whether this is the case for RYGB as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.