Evidence map›Paper›PMID 25157073›Full record

ArticleDatabase : the journal of biological databases and curation2014

Overview of the gene ontology task at BioCreative IV.

Yuqing Mao, Kimberly Van Auken, Donghui Li, Cecilia N Arighi, Peter McQuilton, G Thomas Hayman, Susan Tweedie, Mary L Schaeffer, Stanley J F Laulederkind, Shur-Jen Wang and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Database : the journal of biological databases and curation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Automatic gene annotation using GO terms from cellular component domain.BMC medical informatics and decision making · 2018
    Article
  10. Article
  11. Article
  12. Article
  13. Semantic annotation in biomedicine: the current landscape.Journal of biomedical semantics · 2017
    Review
  14. Review
  15. Article
  16. Biomarker identification of hepatocellular carcinoma using a methodical literature mining strategy.Database : the journal of biological databases and curation · 2017
    Article
  17. Article
  18. Article
  19. Text mining resources for the life sciences.Database : the journal of biological databases and curation · 2016
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yuqing MaoNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Kimberly Van AukenNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Donghui LiNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Cecilia N ArighiNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Peter McQuiltonNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
G Thomas HaymanNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Susan TweedieNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Mary L SchaefferNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Stanley J F LaulederkindNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Shur-Jen WangNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Julien GobeillNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Patrick RuchNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Anh Tuan LuuNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Jung-Jae KimNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Jung-Hsien ChiangNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Yu-De ChenNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Chia-Jung YangNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Hongfang LiuNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Dongqing ZhuNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Yanpeng LiNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Hong YuNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Ehsan EmadzadehNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Graciela GonzalezNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Jian-Ming ChenNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Hong-Jie DaiNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti
Zhiyong LuNational Center for Biotechnology Information (NCBI), National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20817, USA WormBase, Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA, TAIR, Department of Plant Biology, The Arabidopsis Information Resource, Carnegie Institution for Science, Stanford, CA 94305, USA, Center for Bioinformatics and Computational Biology, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA, FlyBase, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK, Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, USDA-ARS Plant Genetics Research Unit and Division of Plant Sciences, Department of Agronomy, University of Missouri, Columbia, MO 65211, USA, HES-SO, HEG, Library and Information Sciences, 7 route de Drize, CH-1227 Carouge, Switzerland, SIBtex, Swiss Institute of Bioinformatics, Rue Michel Servet 1, 1211 Geneva 4, Switzerland, School of Computer Engineering, Nanyang Technological University, Block N4, #02a-32, Nanyang Avenue, Singapore 639798, Department of Computer Science and Information Engineering, National Cheng-Kung University, No. 1, University Rd., Tainan 701, Taiwan, Republic of China, Department of Radiology, Mackay Memorial Hospital, Taitung Branch, Lane 303 Chang Sha St. Taitung, Taiwan, Republic of China, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA, Department of Computer Science, University of Delaware, 101 Smith Hall, Newark, DE 19716, USA, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North (AC7-059), Worcester, MA 01655 USA, Department of Biomedical Informatics, Arizona State University, 13212 East Shea Boulevard Scottsdale, AZ 85259 USA, Institute of Information Science, Academia Sinica, 128 Academia Road, Secti

Funding

Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7M
Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
Named Entity Recognition and Relationship Extraction in BiomedicineZIALM091813 · NLM · NATIONAL LIBRARY OF MEDICINE · PI LU, ZHIYONG · 2013 to 2022
$13.4M
Biocreative Conference GrantR13GM109648 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ARIGHI, CECILIA NOEMI, COHEN, KEVIN B. · 2014 to 2016
$36k
Medical Research Council G1000968NHGRI NIH HHS U41 HG000739NHGRI NIH HHS U41-HG000739NHGRI NIH HHS U41-HG002223NHGRI NIH HHS U41 HG002273NHGRI NIH HHS U41-HG002273NIGMS NIH HHS R13 GM109648NLM NIH HHS R01LM009959A1
6 · The paper itself

Abstract

Gene ontology (GO) annotation is a common task among model organism databases (MODs) for capturing gene function data from journal articles. It is a time-consuming and labor-intensive task, and is thus often considered as one of the bottlenecks in literature curation. There is a growing need for semiautomated or fully automated GO curation techniques that will help database curators to rapidly and accurately identify gene function information in full-length articles. Despite multiple attempts in the past, few studies have proven to be useful with regard to assisting real-world GO curation. The shortage of sentence-level training data and opportunities for interaction between text-mining developers and GO curators has limited the advances in algorithm development and corresponding use in practical circumstances. To this end, we organized a text-mining challenge task for literature-based GO annotation in BioCreative IV. More specifically, we developed two subtasks: (i) to automatically locate text passages that contain GO-relevant information (a text retrieval task) and (ii) to automatically identify relevant GO terms for the genes in a given article (a concept-recognition task). With the support from five MODs, we provided teams with >4000 unique text passages that served as the basis for each GO annotation in our task data. Such evidence text information has long been recognized as critical for text-mining algorithm development but was never made available because of the high cost of curation. In total, seven teams participated in the challenge task. From the team results, we conclude that the state of the art in automatically mining GO terms from literature has improved over the past decade while much progress is still needed for computer-assisted GO curation. Future work should focus on addressing remaining technical challenges for improved performance of automatic GO concept recognition and incorporating practical benefits of text-mining tools into real-world GO annotation. DATABASE URL: http://www.biocreative.org/tasks/biocreative-iv/track-4-GO/.

Indexed as

Data MiningGene OntologyAlgorithmsComputational BiologyHumansMolecular Sequence AnnotationReproducibility of Results

Identifiers

PMID25157073
PMCPMC4142793

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