ArticleCell2014
A molecular framework for temperature-dependent gating of ion channels.
Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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Who cites it
73 citing papers in PubMed.
- Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026Review
- Molecular basis for cold and menthol sensing by mammalian TRPM8.Nature communications · 2026Article
- Thermal preconditioning of targeted tissue enhances pulsed field ablation lesions.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Temperature-dependent functional inversion of CaMolecular brain · 2026Article
- Mechanism of lipid-dependent cold sensitivity in a model ion channel.Nature communications · 2026Article
- All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level.Biophysical journal · 2026Article
- Therapeutic Hypothermia Ameliorates Apoptosis and Cerebral Injury by Upregulating HECTD1-mediated Ubiquitination and VDAC3 Degradation in a Rat CPR Model.International journal of medical sciences · 2026Article
- Rational tuning of temperature sensitivity of the TRPM8 channel.EMBO reports · 2025Article
- Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network.Pflugers Archiv : European journal of physiology · 2025Article
- HCN4 channels sense temperature and determine heart rate responses to heat.Nature communications · 2025Article
- Protein dynamics underlies strong temperature dependence of heat receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Wireless neuromodulation at submillimeter precision via a microwave split-ring resonator.Science advances · 2024Article
- Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Fast and serious: A new method to study ion channel thermodynamics.Biophysical journal · 2023Article
- Ion channel thermodynamics studied with temperature jumps measured at the cell membrane.Biophysical journal · 2023Article
- Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.Frontiers in molecular neuroscience · 2023Review
- A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation.Temperature (Austin, Tex.) · 2023Review
- Yoda1's energetic footprint on Piezo1 channels and its modulation by voltage and temperature.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ratio of Hydrophobic-Hydrophilic and Positive-Negative Residues at Lipid-Water-Interface Influences Surface Expression and Channel Gating of TRPV1.The Journal of membrane biology · 2022Article
- Investigating gating mechanisms of ion channels using temperature-resolved cryoEM.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2021Article
13 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Perception of heat or cold in higher organisms is mediated by specialized ion channels whose gating is exquisitely sensitive to temperature. The physicochemical underpinnings of this temperature-sensitive gating have proven difficult to parse. Here, we took a bottom-up protein design approach and rationally engineered ion channels to activate in response to thermal stimuli. By varying amino acid polarities at sites undergoing state-dependent changes in solvation, we were able to systematically confer temperature sensitivity to a canonical voltage-gated ion channel. Our results imply that the specific heat capacity change during channel gating is a major determinant of thermosensitive gating. We also show that reduction of gating charges amplifies temperature sensitivity of designer channels, which accounts for low-voltage sensitivity in all known temperature-gated ion channels. These emerging principles suggest a plausible molecular mechanism for temperature-dependent gating that reconcile how ion channels with an overall conserved transmembrane architecture may exhibit a wide range of temperature-sensing phenotypes. :
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.