Evidence map›Paper›PMID 25156894›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2014

Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations.

Y Ma, K L Tucker, C E Smith, Y C Lee, T Huang, K Richardson, L D Parnell, C Q Lai, K L Young, A E Justice and 3 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01231958 completednot on this map

The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities

TypeobservationalSponsorUniversity of Massachusetts, LowellRan2004 to 2017Enrolled1,650ConditionsCardiovascular Risk FactorArmsThe Heart Healthy Initiative for Hispanic Adults (HIP)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Trial
  4. Trial
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Y MaJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
K L TuckerClinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
C E SmithJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Y C LeeJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
T HuangDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
K RichardsonJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
L D ParnellJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
C Q LaiJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
K L YoungDepartment of Epidemiology and Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
A E JusticeDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Y ShaoDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
K E NorthDepartment of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
J M OrdovásJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain. Electronic address: jose.ordovas@tufts.edu.
Tufts University · USUniversity of North Carolina at Chapel Hill · USHarvard University · USMadrid Institute for Advanced Studies · ESUniversity of Massachusetts Lowell · US

Funding

STATISTICSP50HL105185 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2010 to 2015
$10.4M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Center for Research/Nutrition &Health among the ElderlyP01AG023394 · NIA · TUFTS UNIVERSITY BOSTON · PI TUCKER, KATHERINE L · 2003 to 2007
$8.1M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
Genetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6M
GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELSR01HL054776 · NHLBI · TUFTS UNIVERSITY BOSTON · PI ORDOVAS, JOSE M. · 1996 to 2010
$2.6M
Genetic Epidemiology of Metabolic Diseases of ObesityR01DK075681 · NIDDK · WASHINGTON UNIVERSITY · PI BORECKI, INGRID BERNADETTE · 2008 to 2011
$2.1M
PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTHR01DK075030 · NIDDK · TUFTS UNIVERSITY BOSTON · PI ORDOVAS, JOSE M. · 2007 to 2009
$989k
Genetic predictors of metabolic responses to dairyK08HL112845 · NHLBI · TUFTS UNIVERSITY BOSTON · PI SMITH, CAREN ELIZABETH · 2013 to 2017
$474k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HL54776NHLBI NIH HHS K08 HL112845NHLBI NIH HHS K08HL112845-01NHLBI NIH HHS P50 HL105185NHLBI NIH HHS R01 HL054776NHLBI NIH HHS T32 HL007055NIA NIH HHS P01 AG023394NIA NIH HHS P01AG023394NICHD NIH HHS R01 HD057194NIDDK NIH HHS DK075030NIDDK NIH HHS R01 DK075030NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01 DK089256NIMHD NIH HHS L60 MD003562
6 · The paper itself

Abstract

BACKGROUND AND

aimsLipoprotein lipase (LPL) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. METHODS AND

resultsWe examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45-75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) (P = 0.002) and waist circumference (WC) (P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) (P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study (n = 1334).

conclusionDietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.

Indexed as

AgedAged, 80 and overAtherosclerosisBody Mass IndexBostonDietFatty Acids, UnsaturatedFeeding BehaviorFemaleHispanic or LatinoHumansIndians, North AmericanLinkage DisequilibriumLipoprotein LipaseMaleMiddle AgedFatty Acids, UnsaturatedLipoprotein LipaseGene-diet interactionLipoprotein lipaseObesityPolyunsaturated fatty acids

Identifiers

PMID25156894
PMCPMC4356006
OpenAlexW1997558985

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.