ArticleInfection and immunity2014
Characterization of urinary tract infection-associated Shiga toxin-producing Escherichia coli.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Hemolytic-uremic syndrome after Escherichia coli urinary tract infection in humans: systematic review of the literature.Journal of nephrology · 2018Pooled it
- Molecular characterization of ESBL-producingFrontiers in cellular and infection microbiology · 2026Article
- Synthesis of biologically active Shiga toxins in cell-free systems.Scientific reports · 2024Article
- Multidrug resistance in pathogenicFrontiers in veterinary science · 2024Article
- Virulence genes, phylogenetic analysis, and antimicrobial resistance of Escherichia coli isolated from urinary tract infection in hospitalized patients and outpatients.Journal of applied genetics · 2022Article
- Characterization of UropathogenicMicroorganisms · 2022Article
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Whole-genome sequence analysis of environmentalMicrobial genomics · 2020Article
- Diversity of Hybrid- and Hetero-PathogenicFrontiers in cellular and infection microbiology · 2020Review
- Structural Insights intoMicroorganisms · 2019Article
- Bacteriophages of the lower urinary tract.Nature reviews. Urology · 2019Review
- Haemolytic uraemic syndrome associated with non shiga toxin-producing Escherichia coli bacteraemia: a case report.BMC nephrology · 2019Article
- Study on the presence of resistant diarrheagenic pathotypes inGastroenterology and hepatology from bed to bench · 2019Article
- Intracellular d-Serine Accumulation Promotes Genetic Diversity via Modulated Induction of RecA in Enterohemorrhagic Escherichia coli.Journal of bacteriology · 2016Article
- Microarray long oligo probe designing for Escherichia coli: an in-silico DNA marker extraction.Central European journal of urology · 2016Article
- A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence.PLoS pathogens · 2016Article
- Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment.Journal of lipid research · 2015Article
- Comparative Genomics and Characterization of Hybrid Shigatoxigenic and Enterotoxigenic Escherichia coli (STEC/ETEC) Strains.PloS one · 2015Article
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11 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Enterohemorrhagic Escherichia coli (EHEC), a subgroup of Shiga toxin (Stx)-producing E. coli (STEC), is a leading cause of diarrhea and hemolytic-uremic syndrome (HUS) in humans. However, urinary tract infections (UTIs) caused by this microorganism but not associated with diarrhea have occasionally been reported. We geno- and phenotypically characterized three EHEC isolates obtained from the urine of hospitalized patients suffering from UTIs. These isolates carried typical EHEC virulence markers and belonged to HUS-associated E. coli (HUSEC) clones, but they lacked virulence markers typical of uropathogenic E. coli. One isolate exhibited a localized adherence (LA)-like pattern on T24 urinary bladder epithelial cells. Since the glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer) are well-known receptors for Stx but also for P fimbriae, a major virulence factor of extraintestinal pathogenic E. coli (ExPEC), the expression of Gb3Cer and Gb4Cer by T24 cells and in murine urinary bladder tissue was examined by thin-layer chromatography and mass spectrometry. We provide data indicating that Stxs released by the EHEC isolates bind to Gb3Cer and Gb4Cer isolated from T24 cells, which were susceptible to Stx. All three EHEC isolates expressed stx genes upon growth in urine. Two strains were able to cause UTI in a murine infection model and could not be outcompeted in urine in vitro by typical uropathogenic E. coli isolates. Our results indicate that despite the lack of ExPEC virulence markers, EHEC variants may exhibit in certain suitable hosts, e.g., in hospital patients, a uropathogenic potential. The contribution of EHEC virulence factors to uropathogenesis remains to be further investigated.
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