ReviewEuropean journal of pediatrics2015
Educational paper: Pathogenesis of infantile haemangioma, an update 2014 (part I).
Review in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Efficacy and adverse effects of oral propranolol in infantile hemangioma: a meta-analysis of comparative studies.World journal of pediatrics : WJP · 2019Pooled it
- Myosin 1b Inhibits the Phenotype of HemECs to Affect the Progression of Infantile Hemangiomas.Clinical, cosmetic and investigational dermatology · 2025Article
- Infantile Hemangioma: Risk Factors and Management in a Preterm Patient-A Case Report.Reports (MDPI) · 2024Article
- Infantile Hemangioma: A Cross-Sectional Observational Study.Life (Basel, Switzerland) · 2023Article
- Association of Infantile Hemangiomas and Retinopathy of Prematurity: Analysis of the Multicenter KID.Biomedicine hub · 2022Article
- 15,16-dihydrotanshinone I inhibits EOMA cells proliferation by interfering in posttranscriptional processing of hypoxia-inducible factor 1.International journal of medical sciences · 2021Article
- miR-4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma.Experimental and therapeutic medicine · 2020Article
- The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas.World journal of plastic surgery · 2018Article
- Treatment of infantile haemangiomas: recommendations of a European expert group.European journal of pediatrics · 2015Review
- Educational paper: therapy of infantile haemangioma--history and current state (part II).European journal of pediatrics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledInfantile haemangioma (IH) is the most frequent childhood tumour. Although it is benign and self-limiting, severe complications can arise due to localisation and fast tumour growth. Management and therapy of IH has changed greatly after 2008 with propranolol. However, the pathogenesis remains elusive. This update provides an overview of all possible mechanisms currently considered. We discuss the possibility that several mechanisms act together, although local hypoxia seems to be important. Clinically, in about half of the cases, an IH is preceded by an anaemic macula (local ischaemia) or a so-called precursor lesion. Laboratory findings indicate stabilisation and an increased transcription activity of hypoxia-inducible factor 1 alpha (HIF1α), leading to up-regulation of its downstream target genes (such as vascular endothelial growth factor (VEGF)), which normally occurs in cases of hypoxia.
conclusionThree main hypotheses have been proposed, namely (1) the theory of tissue hypoxia, (2) the theory of embolization of placental endothelial cells and (3) the theory of increased angiogenic and vasculogenic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.