Evidence map›Paper›PMID 25156611›Full record

ArticleAlcoholism, clinical and experimental research2014

Commentary: catching a conserved mechanism of ethanol teratogenicity.

C Ben Lovely, Johann K Eberhart

Open access · greenAbstract readComment
In one paragraph

Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Zebrafish models of fetal alcohol spectrum disorders.Genesis (New York, N.Y. : 2000) · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C Ben LovelyDepartment of Molecular Biosciences, Waggoner Center for Alcohol & Addiction Research, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas.
Johann K Eberhart
The University of Texas at Austin · US

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
Causes of Variability in Craniofacial DiseaseR01DE020884 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI EBERHART, JOHANN K · 2010 to 2019
$3.4M
NIAAA NIH HHS U24 AA014811NIAAA NIH HHS U24AA014811NIDCR NIH HHS R01 DE020884NIDCR NIH HHS R01DE020884
6 · The paper itself

Abstract

backgroundDue to its profound impact on human development, ethanol (EtOH) teratogenicity is a field of intense study. The complexity of variables that influence the outcomes of embryonic or prenatal EtOH exposure compels the use of animal models in which these variables can be isolated.

methodsNumerous model systems have been used in these studies. The zebrafish is a powerful model system, which has seen a recent increase in usage for EtOH studies.

resultsThose using zebrafish for alcohol studies often face 2 questions: (i) How physiologically relevant are the doses of EtOH administered to zebrafish embryos? and (ii) Will the mechanisms of EtOH teratogenesis be conserved to other model systems and human?

conclusionsThe current article by Flentke and colleagues () helps to shed important light on these questions and clearly demonstrates that the zebrafish will be a valuable model system with which to understand EtOH teratogenicity.

Indexed as

AnimalsFetal Alcohol Spectrum DisordersNeurotoxicity SyndromesFetal Alcohol Spectrum DisorderZebrafish

Identifiers

PMID25156611
PMCPMC4147959
OpenAlexW1982364071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.