ArticleJournal of immunology (Baltimore, Md. : 1950)2014
TGF-β-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Divergent Immunomodulatory Roles of Fungal DNA in Shaping Treg and Inflammatory Responses.Journal of fungi (Basel, Switzerland) · 2025Article
- Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk.Aging and disease · 2025Review
- Mechanistic roles of neutrophil heterogeneity in tumour pathogenesis.Frontiers in immunology · 2025Review
- Measurements of Treg Cell Induction by Candida albicans DNA Using Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Treg Cells and Epigenetic Regulation.Advances in experimental medicine and biology · 2021Article
- TNF-TNFR2 Signal Plays a Decisive Role in the Activation of CD4Advances in experimental medicine and biology · 2021Article
- Tregs in Autoimmune Uveitis.Advances in experimental medicine and biology · 2021Article
- Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics.Advances in experimental medicine and biology · 2021Article
- Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3Annals of translational medicine · 2019Article
- The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- A panel of 4 biomarkers for the early diagnosis and therapeutic efficacy of aGVHD.JCI insight · 2019Article
- Blockade of miR-142-3p promotes anti-apoptotic and suppressive function by inducing KDM6A-mediated H3K27me3 demethylation in induced regulatory T cells.Cell death & disease · 2019Article
- Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells.Cells · 2019Review
- Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways.Cell death & disease · 2019Article
- Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemiaAmerican journal of translational research · 2019Article
- TGF-β-Induced CD8Frontiers in immunology · 2018Article
- Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3Journal of immunology research · 2018Article
- Update of humanized animal disease models in studying Graft-versus-host disease.Human vaccines & immunotherapeutics · 2018Article
- Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.Frontiers in immunology · 2018Review
- In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 3 countries.
Funding
Abstract
The use of TGF-β-induced CD4(+)Foxp3(+) T cells (induced regulatory T cells [iTregs]) is an important prevention and treatment strategy in autoimmune diseases and other disorders. However, the potential use of iTregs as a treatment modality for acute graft-versus-host disease (aGVHD) has not been realized because they may be unstable and less suppressive in this disease. We restudied the ability of iTregs to prevent and treat aGVHD in two mouse models. Our results showed that, as long as an appropriate iTreg-generation protocol is used, these iTregs consistently displayed a potent ability to control aGVHD development and reduce mortality in the aGVHD animal models. iTreg infusion markedly suppressed the engraftment of donor CD8(+) cells and CD4(+) cells, the expression of granzyme A and B, the cytotoxic effect of donor CD8(+) cells, and the production of T cell cytokines in aGVHD. Therefore, we conclude that as long as the correct methods for generating iTregs are used, they can prevent and even treat aGVHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.