Evidence map›Paper›PMID 25156214›Full record

SynthesisThe pharmacogenomics journal2014

Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents.

H F Burnett, R Tanoshima, W Chandranipapongse, P Madadi, S Ito, W J Ungar

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The pharmacogenomics journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Pharmacogenetics: Opportunities for theAnnual review of pharmacology and toxicology · 2025
    Review
  5. Article
  6. Defining Clinical Utility of Germline Indicators of Toxicity Risk: A Perspective.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  7. Review
  8. Article
  9. Associations between theOncoTargets and therapy · 2018
    Article
  10. Article
  11. Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2015
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

H F BurnettProgram of Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
R TanoshimaClinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada.
W ChandranipapongseClinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada.
P MadadiClinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada.
S Ito1] Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada [2] Departments of Medicine, Pharmacology and Pharmacy, and Paediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
W J Ungar1] Program of Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada [2] Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A common pharmacogenomic test is for thiopurine S-methyltransferase (TPMT) status prior to treatment with thiopurine drugs, used to treat auto-immune conditions and pediatric cancer. Guidelines assist practitioners with decisions regarding testing and treatment. The objectives were to conduct a systematic review and critical appraisal of guidance documents with statements regarding TPMT testing and thiopurine dosing. Guidelines, clinical protocols and care pathways from all disciplines were eligible. A quality appraisal was carried out by three appraisers using the Appraisal of Guidelines for Research and Evaluation II. Of the 20 documents found, 5 recommended genotyping while 4 recommended phenotyping. Thirteen documents provided dosing recommendations based on TPMT status. The quality appraisal revealed wide variation across documents. The National Institute for Health and Clinical Excellence and Cincinnati Children's Hospital guidelines demonstrated the highest overall quality with scores of 79 and 76, respectively. Low-scoring documents failed to use systematic methods to develop recommendations or to provide evidence to support recommendations. Guidance documents that included dosing recommendations demonstrated higher quality.

Indexed as

Antimetabolites, AntineoplasticHumansMercaptopurineMethyltransferasesAntimetabolites, AntineoplasticMercaptopurineMethyltransferasesthiopurine methyltransferase

Identifiers

PMID25156214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.