ArticleJournal of neurology2014
Heritability in frontotemporal dementia: more missing pieces?
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Short tandem repeat expansions in patients with neurodegenerative dementia.EBioMedicine · 2026Article
- Genetic structure of different ethnic populations at the frontotemporal dementia risk loci.PloS one · 2025Article
- A scoping review of the unique landscape and challenges associated with dementia in the Western Pacific region.The Lancet regional health. Western Pacific · 2024Article
- An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation.Frontiers in immunology · 2024Article
- Genetic testing in dementia - utility and clinical strategies.Nature reviews. Neurology · 2021Review
- Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling.Advances in experimental medicine and biology · 2021Article
- Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road.Frontiers in psychiatry · 2021Review
- C9ORF72 hexanucleotide repeat expansion with Alzheimer's disease-like clinical phenotype: A case report with results from neuropsychology, CSF, FDG-PET, and PiB-PET.Clinical case reports · 2020Article
- Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity.Human molecular genetics · 2020Article
- Heritability in frontotemporal tauopathies.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- An update on genetic frontotemporal dementia.Journal of neurology · 2019Review
- Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.Scientific reports · 2019Article
- The Use of Biomarkers and Genetic Screening to Diagnose Frontotemporal Dementia: Evidence and Clinical Implications.Frontiers in neuroscience · 2019Article
- Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes.American journal of Alzheimer's disease and other dementias · 2018Article
- Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.Brain : a journal of neurology · 2018Article
- Intrafamilial Phenotypic Variability in theFrontiers in psychology · 2018Article
- Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease.BMC neurology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frontotemporal dementia (FTD) is reportedly highly heritable, even though a recognized genetic cause is often absent. To explain this contradiction, we explored the "strength" of family history in FTD, Alzheimer's disease (AD), and controls. Clinical syndromes associated with heritability of FTD and AD were also examined. FTD and AD patients were recruited from an FTD-specific research clinic, and patients were further sub-classified into FTD or AD phenotypes. The strength of family history was graded using the Goldman score (GS), and GS of 1-3 was regarded as a "strong" family history. A subset of FTD patients underwent screening for the main genetic causes of FTD. In total, 307 participants were included (122 FTD, 98 AD, and 87 controls). Although reported positive family history did not differ between groups, a strong family history was more common in FTD (FTD 17.2 %, AD 5.1 %, controls 2.3 %, P < 0.001). The bvFTD and FTD-ALS groups drove heritability, but 12.2 % of atypical AD patients also had a strong family history. A pathogenic mutation was identified in 16 FTD patients (10 C9ORF72 repeat expansion, 5 GRN, 1 MAPT), but more than half of FTD patients with a strong family history had no mutation detected. FTD is a highly heritable disease, even more than AD, and patients with bvFTD and FTD-ALS drive this heritability. Atypical AD also appears to be more heritable than typical AD. These results suggest that further genetic influences await discovery in FTD.
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Registered trials
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