ArticleScientific reports2014
Novel 3D microscopic analysis of human placental villous trees reveals unexpected significance of branching angles.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Review of Biomechanics Analysis of the Umbilical-Placenta System With Regards to Diseases.Frontiers in physiology · 2021Pooled it
- Three-Dimensional Architecture of Placental Villous Branching in the Normal Human Placenta: A Scoping Review.Cureus · 2026Review
- Three-dimensional visualization of the cytotrophoblast layer of human term chorionic villi.Histochemistry and cell biology · 2025Article
- Article
- High-resolution X-ray phase-contrast tomography of human placenta with different wavefront markers.Scientific reports · 2025Article
- Three-dimensional microarchitecture of the human placental villous tree in health and disease.Frontiers in cell and developmental biology · 2025Review
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.Scientific reports · 2018Article
- Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease.Scientific reports · 2017Article
- Article
- Novel 3D light microscopic analysis of IUGR placentas points to a morphological correlate of compensated ischemic placental disease in humans.Scientific reports · 2016Article
- Multiscale modelling of the feto-placental vasculature.Interface focus · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
The villous trees of human placentas delineate the fetomaternal border and are complex three-dimensional (3D) structures. Thus far, they have primarily been analyzed as thin, two-dimensional (2D) histological sections. However, 2D sections cannot provide access to key aspects such as branching nodes and branch order. Using samples taken from 50 normal human placentas at birth, in the present study we show that analysis procedures for 3D reconstruction of neuronal dendritic trees can also be used for analyzing trees of human placentas. Nodes and their branches (e.g., branching hierarchy, branching angles, diameters, and lengths of branches) can be efficiently measured in whole-mount preparations of isolated villous trees using high-end light microscopy. Such data differ qualitatively from the data obtainable from histological sections and go substantially beyond the morphological horizon of such histological data. Unexpectedly, branching angles of terminal branches of villous trees varied inversely with the fetoplacental weight ratio, a widely used clinical parameter. Since branching angles have never before been determined in the human placenta, this result requires further detailed studies in order to fully understand its impact.
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