ArticlePharmacogenomics2014
Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes.
Article in Pharmacogenomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for a sex-diverging association between alcohol use and body mass index.Scientific reports · 2022Pooled it
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- A robust and powerful GWAS method for family trios supporting within-family Mendelian randomization analysis.Research square · 2025Article
- Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report.Genes, brain, and behavior · 2025Article
- LASSO-type instrumental variable selection methods with an application to Mendelian randomization.Statistical methods in medical research · 2025Article
- Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder.Advances in drug and alcohol research · 2023Review
- Multi-scale inference of genetic trait architecture using biologically annotated neural networks.PLoS genetics · 2021Article
- Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.Addiction biology · 2020Article
- Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults.Behavior genetics · 2017Article
- Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence?The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017Article
- Genome-wide association study of body mass index in subjects with alcohol dependence.Addiction biology · 2017Article
- Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.Alcohol (Fayetteville, N.Y.) · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimFamilial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study. MATERIALS &
methodsGrowth curve analyses of BMI data collected at approximately yearly intervals and obesity status (BMI > 30) were examined.
resultsHigh-risk males were found to have higher BMI than low-risk males, beginning at age 15 years (2.0 kg/m(2) difference; p = 0.046), persisting through age 19 years (3.3 kg/m(2) difference; p = 0.005). CHRM2 genotypic variance predicted longitudinal BMI and obesity status. Interactions with risk status and sex were also observed for DRD2 and FTO gene variation.
conclusionVariation at loci implicated in addiction may be influential in determining susceptibility to increased BMI in childhood and adolescence.
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