Evidence map›Paper›PMID 25155880›Full record

ArticleMolecular psychiatry2015

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.

C C Clements, V M Castro, S R Blumenthal, H R Rosenfield, S N Murphy, M Fava, J L Erb, S E Churchill, A J Kaimal, A E Doyle and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 10 pooled it
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 10 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

C C Clements1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
V M Castro1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, MA, USA [3] Laboratory of Computer Science and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
S R Blumenthal1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
H R Rosenfield1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
S N Murphy1] Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, MA, USA [2] Laboratory of Computer Science and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
M FavaDepression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
J L ErbDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
S E ChurchillInformation Systems, Partners HealthCare System, New Research Building, Boston, MA, USA.
A J KaimalDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.
A E Doyle1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
E B Robinson1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Analytic and Translational Genomics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
J W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
I S KohaneDepartment of Medicine, Brigham and Women's Hospital, New Research Building, Boston, MA, USA.
R H Perlis1] Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USMassachusetts General Hospital · USMass General Brigham · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
Building a Risk Stratification Model for Treatment Resistance in Major DepressiveR01MH086026 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PERLIS, ROY H. · 2009 to 2011
$1.3M
In utero antidepressant exposures and risk for autismR01MH100286 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PERLIS, ROY H. · 2013 to 2015
$1.0M
NCRR NIH HHS UL1 RR025758NIMH NIH HHS 5R01MH100286-02NIMH NIH HHS R01 MH086026NIMH NIH HHS R01 MH100286NLM NIH HHS 2U54LM008748NLM NIH HHS U54 LM008748PHS HHS NIMH R01MH086026
6 · The paper itself

Abstract

Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system were identified from electronic health records (EHR), and each diagnostic group was matched 1:3 with children without ASD or ADHD. All children were linked with maternal health data using birth certificates and EHRs to determine prenatal medication exposures. Multiple logistic regression was used to examine association between prenatal antidepressant exposures and ASD or ADHD risk. A total of 1377 children diagnosed with ASD and 2243 with ADHD were matched with healthy controls. In models adjusted for sociodemographic features, antidepressant exposure prior to and during pregnancy was associated with ASD risk, but risk associated with exposure during pregnancy was no longer significant after controlling for maternal major depression (odds ratio (OR) 1.10 (0.70-1.70)). Conversely, antidepressant exposure during but not prior to pregnancy was associated with ADHD risk, even after adjustment for maternal depression (OR 1.81 (1.22-2.70)). These results suggest that the risk of autism observed with prenatal antidepressant exposure is likely confounded by severity of maternal illness, but further indicate that such exposure may still be associated with ADHD risk. This risk, modest in absolute terms, may still be a result of residual confounding and must be balanced against the substantial consequences of untreated maternal depression.

Indexed as

Antidepressive AgentsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCase-Control StudiesChildChild, PreschoolEnglandFemaleHumansLogistic ModelsMaleMother-Child RelationsPregnancyPrenatal Exposure Delayed EffectsRisk FactorsAntidepressive Agents

Identifiers

PMID25155880
PMCPMC4427538
OpenAlexW2071055980

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.