ArticleJournal of molecular evolution2014
Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Coevolution of RNase P and the ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning.Nature communications · 2022Article
- Article
- Fitness landscape of a dynamic RNA structure.PLoS genetics · 2021Article
- In vitro selections with RNAs of variable length converge on a robust catalytic core.Nucleic acids research · 2021Article
- Big on Change, Small on Innovation: Evolutionary Consequences of RNA Sequence Duplication.Journal of molecular evolution · 2019Article
- High-throughput screening of biomolecules using cell-free gene expression systems.Synthetic biology (Oxford, England) · 2018Review
- Origin of life in a digital microcosm.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences.Nucleic acids research · 2017Article
- Evolution of complex adaptations in molecular systems.Nature ecology & evolution · 2017Article
- Chemical systems, chemical contiguity and the emergence of life.Beilstein journal of organic chemistry · 2017Review
- Amplification of RNA by an RNA polymerase ribozyme.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Environmental changes bridge evolutionary valleys.Science advances · 2016Article
- Elucidating the molecular architecture of adaptation via evolve and resequence experiments.Nature reviews. Genetics · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The relative contributions of adaptive selection and neutral drift to genetic change are unknown but likely depend on the inherent abundance of functional genotypes in sequence space and how accessible those genotypes are to one another. To better understand the relative roles of selection and drift in evolution, local fitness landscapes for two different RNA ligase ribozymes were examined using a continuous in vitro evolution system under conditions that foster the capacity for neutral drift to mediate genetic change. The exploration of sequence space was accelerated by increasing the mutation rate using mutagenic nucleotide analogs. Drift was encouraged by carrying out evolution within millions of separate compartments to exploit the founder effect. Deep sequencing of individuals from the evolved populations revealed that the distribution of genotypes did not escape the starting local fitness peak, remaining clustered around the sequence used to initiate evolution. This is consistent with a fitness landscape where high-fitness genotypes are sparse and well isolated, and suggests, at least in this context, that neutral drift alone is not a primary driver of genetic change. Neutral drift does, however, provide a repository of genetic variation upon which adaptive selection can act.
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