ArticleArthritis & rheumatology (Hoboken, N.J.)2014
Lumbar spinal stenosis is a highly genetic condition partly mediated by disc degeneration.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
- Genetic architecture of lumbar spinal stenosis.Nature communications · 2026Pooled it
- A genomic structural equation modelling analysis of the shared genetic architecture of the aging spine.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Case Report: Diagnostic anchoring in spinal dural arteriovenous fistula: a case-based analysis of clinical-radiological mismatch and delayed recognition.Frontiers in medicine · 2026Article
- Surgically treated degenerative cervical spine diseases in twins.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Article
- Risk Factors for Surgical Treatment of Lumbar Degenerative Disc Disease in Middle-aged and Older Women: A Prospective Case-Control Study of 2370 Subjects.Orthopaedic surgery · 2024Article
- Single-Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis.Research (Washington, D.C.) · 2024Article
- Article
- Establishment of a New Model of Lumbar Intervertebral Disc Degeneration With Pathological Characteristics.Global spine journal · 2023Article
- Genetics of Intervertebral Disc Degeneration.Current osteoporosis reports · 2023Review
- Circular RNA hsa_circ_0001658 Inhibits Intervertebral Disc Degeneration Development by Regulating hsa-miR-181c-5p/FAS.Computational and mathematical methods in medicine · 2021Article
- Current concepts and recent advances in understanding and managing lumbar spine stenosis.F1000Research · 2019Review
- Characteristics and determinants of clinical symptoms in radiographic lumbar spinal stenosis in a tertiary health care centre in sub-Saharan Africa.BMC musculoskeletal disorders · 2017Article
- Dimensional changes of cervical and lumbar bony spinal canals in one generation in Western Switzerland: a computed tomography study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.Journal of molecular medicine (Berlin, Germany) · 2016Article
- The paradoxical relationship between ligamentum flavum hypertrophy and developmental lumbar spinal stenosis.Scoliosis and spinal disorders · 2016Article
- The cost effectiveness of dynamic and static interspinous spacer for lumbar spinal stenosis compared with laminectomy.Medical journal of the Islamic Republic of Iran · 2016Article
- Change in onset times of the abdominal muscles following functional task in lumbar spinal stenosis.Journal of exercise rehabilitation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Objective. Lumbar spinal stenosis is one of the most commonly diagnosed spinal disorders in older adults. Although the pathophysiology of the clinical syndrome is not well understood, a narrow central canal or intervertebral foramen is an essential or defining feature. The aim of the present study was to estimate the magnitude of genetic versus environmental influences on central lumbar spinal stenosis and to investigate disc degeneration and stature or bone development as possible genetic pathways.Methods. A classic twin study with multivariate analyses considering lumbar level and other covariates was conducted. The study sample comprised 598 male twins (147 monozygotic and 152 dizygotic pairs), 35-70 years of age, from the population-based Finnish Twin Cohort. The primary phenotypes were central lumbar stenosis as assessed qualitatively on magnetic resonance imaging (MRI) and quantitatively measured dural sac cross-sectional area. Additional phenotypes (to examine possible genetic pathways) included disc bulging and standing height, as an indicator of overall skeletal size or development.Results. The heritability estimate (h²) for qualitatively assessed central lumbar spinal stenosis on MRI was 66.9% (95% confidence interval [95% CI] 56.8,74.5). The broad-sense heritability estimate for dural sac cross-sectional area was 81.2% (95% CI 74.5, 86.1),with a similar magnitude of genetic influences across lumbar levels (h²=72.4–75.6). The additive genetic correlation of quantitatively assessed stenosis and disc bulging was extremely high. There was no indication of shared genetic influences between stenosis and stature.Conclusion. Central lumbar spinal stenosis and associated dural sac dimensions are highly genetic, and disc degeneration (bulging) appears to be one pathway through which genes influence spinal stenosis.
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Registered trials
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