ArticleImmunology and cell biology2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Article in Immunology and cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- The cat's out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense.ImmunoHorizons · 2025Review
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mutual regulations betweenFrontiers in immunology · 2024Review
- IFNs in host defence and parasite immune evasion duringFrontiers in immunology · 2024Review
- The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them.The Journal of experimental medicine · 2021Review
- Secreted Effectors Modulating Immune Responses toLife (Basel, Switzerland) · 2021Review
- Toxoplasma gondii infection and its implications within the central nervous system.Nature reviews. Microbiology · 2021Review
- Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol.PLoS pathogens · 2021Article
- Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020Review
- The GRA15 protein fromThe Journal of biological chemistry · 2019Article
- Article
- Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.Nature communications · 2019Article
- Association of TREM-1, IL-1β, IL-33/ST2, and TLR Expressions With the Pathogenesis of Ocular Toxoplasmosis in Mouse Models on Different Genetic Backgrounds.Frontiers in microbiology · 2019Article
- Sources of Type I Interferons in Infectious Immunity: Plasmacytoid Dendritic Cells Not Always in the Driver's Seat.Frontiers in immunology · 2019Review
- Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8αJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β.Scientific reports · 2017Article
- Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The classic anti-viral cytokine interferon (IFN)-β can be induced during parasitic infection, but relatively little is know about the cell types and signaling pathways involved. Here we show that inflammatory monocytes (IMs), but not neutrophils, produce IFN-β in response to T. gondii infection. This difference correlated with the mode of parasite entry into host cells, with phagocytic uptake predominating in IMs and active invasion predominating in neutrophils. We also show that expression of IFN-β requires phagocytic uptake of the parasite by IMs, and signaling through Toll-like receptors (TLRs) and MyD88. Finally, we show that IMs are major producers of IFN-β in mesenteric lymph nodes following in vivo oral infection of mice, and mice lacking the receptor for type I IFN-1 show higher parasite loads and reduced survival. Our data reveal a TLR and internalization-dependent pathway in IMs for IFN-β induction to a non-viral pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.