ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015
Venous thromboembolism risk factors in Chinese non-small cell lung cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03581708 (Real-world Study of the Incidence and Risk Factors of Venous Thromboembolism), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Real-world Study of the Incidence and Risk Factors of Venous Thromboembolism (VTE) in Chinese Advanced Stage Lung Cancer
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Incidence and risk factors of VTE in lung cancer: a meta-analysis.Annals of medicine · 2024Pooled it
- Prevalence and clinical characteristics of venous thromboembolism in patients with lung cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Could PD-L1 positivity be associated with venous thrombosis in patients with non-small cell lung cancer?Journal of thrombosis and thrombolysis · 2023Observational
- Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry.Frontiers in oncology · 2023Article
- Association of Venous Thromboembolism and Early Mortality in Patients with Newly Diagnosed Metastatic Non-Small Cell Lung Cancer.Cancer management and research · 2021Article
- The EGFR-rearranged adenocarcinoma is associated with a high rate of venous thromboembolism.Annals of translational medicine · 2019Article
- Article
- [Risk Factors Associated with Venous Thromboembolism after Lung Cancer Surgery: A Single-center Study].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2018Article
- Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma.Journal of gastrointestinal cancer · 2018Article
- Risk factors and prognosis value of venous thromboembolism in patients with advanced non-small cell lung cancer: a case-control study.Journal of thoracic disease · 2017Article
- Mutational status predicts the risk of thromboembolic events in lung adenocarcinoma.Multidisciplinary respiratory medicine · 2017Article
- Persistent neutrophilia is a marker for an increased risk of venous thrombosis.Journal of thrombosis and thrombolysis · 2016Article
- Complications and 30-day Outcomes Associated With Venous Thromboembolism in the Pediatric Orthopaedic Surgical Population.The Journal of the American Academy of Orthopaedic Surgeons · 2016Article
- A new Score for Predicting Immune Checkpoint Inhibitor-Associated Thrombosis in Cancer Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCertain clinicopathological factors contribute to the development of venous thromboembolism (VTE) in lung cancer. The aim of the current study was to assess the incidence of and the potential risk factors associated with the development of VTE in Chinese lung cancer patients.
methodsPatients with lung cancer in our center were screened for VTE from January 2004 to July 2013. One VTE case was matched with two controls according to gender, pathology, clinical stage, and anticancer therapy.
resultsAmong the 4,726 patient records screened, 61 (1.3 %) VTE cases with non-small cell lung cancer (NSCLC) were identified, including 58 (95.1 %) with adenocarcinoma and 59 (96.7 %) with advanced stage tumors (IIIb and IV). Serous effusion (OR 2.089, 95 % CI 1.022-4.270, P = 0.043), fever (OR 8.999, 95 % CI 1.688-47.968, P = 0.010), increased leukocytes (OR 4.136, 95 % CI 1.957-8.738, P < 0.001), hyponatremia (< 130 mmol/L, OR 5.335, 95 % CI 1.366-20.833, P = 0.016), and increased alanine aminotransferase (ALT) (OR 3.879, 95 % CI 1.514-9.936, P = 0.005) were associated with an increased risk of VTE. Patients with poor performance status (PS) (≥ 2 vs. < 1) (HR 1.574, 95 % CI 1.112-2.228, P = 0.010) and serous effusion (HR 1.571, 95% CI 1.114-2.215, P = 0.010) tended to have a poor prognosis. There was no difference in overall survival between VTE (median 15.2 months, 95 % CI 11.6-18.9) and control patients (median 16.3 months, 95 % CI 14.1-18.4, P = 0.184; HR 1.273, 95 % CI 0.890-1.820, P = 0.185).
conclusionsClinical characteristics such as serous effusion, fever, increased leukocytes, hyponatremia, and increased ALT are potential risk factors for VTE in NSCLC. Poor PS and serous effusion imply poor prognosis for NSCLC patients, most of which have adenocarcinomas and advanced stage.
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