Evidence map›Paper›PMID 25154941›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2014

Noninvasive assessment of liver fibrosis using ultrasound-based shear wave measurement and comparison to magnetic resonance elastography.

Heng Zhao, Jun Chen, Duane D Meixner, Hua Xie, Vijay Shamdasani, Shiwei Zhou, Jean-Luc Robert, Matthew W Urban, William Sanchez, Matthew R Callstrom and 3 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Fourier-Domain Shift Matching: A Robust Time-of-Flight Approach for Shear Wave Speed Estimation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018
    Article
  11. Article
  12. Article
  13. Prospective comparison of magnetic resonance imaging to transient elastography and serum markers for liver fibrosis detection.Liver international : official journal of the International Association for the Study of the Liver · 2016
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Heng ZhaoDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Jun ChenDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Duane D MeixnerDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Hua XieDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Vijay ShamdasaniDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Shiwei ZhouDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Jean-Luc RobertDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Matthew W UrbanDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
William SanchezDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Matthew R CallstromDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Richard L EhmanDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
James F GreenleafDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.).
Shigao ChenDepartments of Physiology and Biomedical Engineering (H.Z., M.W.U., J.F.G., S.C.), Radiology (J.C., D.D.M., M.R.C., R.L.E.), and Gastroenterology and Hepatology (W.S.), Mayo Clinic College of Medicine, Rochester, Minnesota USA; Philips Research North America, Briarcliff Manor, New York USA (H.X., S.Z., J.-L.R.); and Philips Healthcare, Bothell, Washington USA (V.S.). chen.shigao@mayo.edu.
WinnMed · USMayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Multidimensional Heart Imaging With UltrasoundR01EB002167 · NIBIB · MAYO CLINIC ROCHESTER · PI GREENLEAF, JAMES FOWLER, PISLARU, CRISTINA · 2003 to 2014
$6.1M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Virtual Biopsy with Ultrasound for Liver Fibrosis StagingR01DK082408 · NIDDK · MAYO CLINIC ROCHESTER · PI CHEN, SHIGAO · 2009 to 2013
$1.6M
NCATS NIH HHS UL1 TR000135NIBIB NIH HHS EB001981NIBIB NIH HHS EB002167NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB002167NIBIB NIH HHS R37 EB001981NIDDK NIH HHS DK082408NIDDK NIH HHS R01 DK082408
6 · The paper itself

Abstract

objectivesMagnetic resonance elastography (MRE) has excellent performance in detecting liver fibrosis and is becoming an alternative to liver biopsy in clinical practice. Ultrasound techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force also have shown promising results for liver fibrosis staging. The objective of this study was to compare ultrasound-based shear wave measurement to MRE.

methodsIn this study, 50 patients (28 female and 22 male; age range, 19-81 years) undergoing liver MRE examinations were studied with an ultrasound scanner modified with shear wave measurement functionality. For each patient, 27 shear wave speed measurements were obtained at various locations in the liver parenchyma away from major vessels. The median shear wave speed from all measurements was used to calculate a representative shear modulus (μ) for each patient. Magnetic resonance elastographic data processing was done by a single analyst blinded to the ultrasound measurement results.

resultsUltrasound and MRE measurements were correlated (r = 0.86; P < .001). Receiver operating characteristic (ROC) analysis was applied to the ultrasound measurement results with the MRE diagnosis as the "ground truth." The area under the ROC curve for separating patients with minimum fibrosis (defined as μ(MRE) ≤2.9 kPa) was 0.89 (95% confidence interval, 0.77-0.95), and the area under the ROC curve for separating patients with advanced fibrosis (defined as μ(MRE) ≥5.0 kPa) was 0.96 (95% confidence interval, 0.87-0.99).

conclusionsResults indicate that the ultrasound-based shear wave measurement correlates with MRE and is a promising method for liver fibrosis staging.

Indexed as

AdultAgedAged, 80 and overElasticity Imaging TechniquesFemaleHumansLiverLiver CirrhosisMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsROC CurveYoung Adultgastrointestinal ultrasoundliver fibrosismagnetic resonance elastographyshear waveultrasound

Identifiers

PMID25154941
PMCPMC4145616
OpenAlexW2061362175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.