ArticleAngewandte Chemie (International ed. in English)2014
Cell-mediated assembly of phototherapeutics.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Engineered cell-biomimetic nanosystems for anti-inflammatory therapy: Targeting, neutralization and immunomodulation.Acta pharmaceutica Sinica. B · 2026Review
- Seeing What Sticks: Anchoring Capabilities of Moieties for Use in Cell-Conveyed Therapeutics.Bioconjugate chemistry · 2025Article
- Photothrombolytics: A light-driven technology for the targeted lysis of thrombi.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Spatiotemporal Control of Biology: Synthetic Photochemistry Toolbox with Far-Red and Near-Infrared Light.ACS chemical biology · 2022Review
- Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair.Bioengineering (Basel, Switzerland) · 2022Review
- Taking phototherapeutics from concept to clinical launch.Nature reviews. Chemistry · 2021Review
- Light-Controlled Release of Therapeutic Proteins from Red Blood Cells.ACS central science · 2021Article
- Targeted Drug Delivery through Optical Control of Cell Lysis.ACS central science · 2021Article
- Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.Chemical reviews · 2020Article
- Photocontrolled activation of small molecule cancer therapeutics.RSC medicinal chemistry · 2020Review
- Optochemical Control of Biological Processes in Cells and Animals.Angewandte Chemie (International ed. in English) · 2018Review
- Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents.Angewandte Chemie (International ed. in English) · 2016Article
- Harnessing cyanine photooxidation: from slowing photobleaching to near-IR uncaging.Current opinion in chemical biology · 2016Review
- Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins.Inorganic chemistry · 2016Article
- Vitamin B12: a tunable, long wavelength, light-responsive platform for launching therapeutic agents.Accounts of chemical research · 2015Article
- A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrOChemical science · 2015Article
- B(12)-mediated, long wavelength photopolymerization of hydrogels.Journal of the American Chemical Society · 2015Article
- EMBO conference series: Chemical Biology 2014.Chembiochem : a European journal of chemical biology · 2014Article
- A near-IR uncaging strategy based on cyanine photochemistry.Journal of the American Chemical Society · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial resolution. However, light-sensitive prodrugs are typically converted to their active forms using short-wavelength irradiation, which displays poor tissue penetrance. We report herein erythrocyte-mediated assembly of long-wavelength-sensitive phototherapeutics. The activating wavelength of the constructs is readily preassigned by using fluorophores with the desired excitation wavelength λ(ex). Drug release from the erythrocyte carrier was confirmed by standard analytical tools and by the expected biological consequences of the liberated drugs in cell culture: methotrexate, binding to intracellular dihydrofolate reductase; colchicine, inhibition of microtubule polymerization; dexamethasone, induced nuclear migration of the glucocorticoid receptor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.