Evidence map›Paper›PMID 25154343›Full record

ReviewCurrent opinion in virology2014

Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections.

Nicholas Renzette, Laura Gibson, Jeffrey D Jensen, Timothy F Kowalik

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Cytomegalovirus Genetic Diversity Following Primary Infection.The Journal of infectious diseases · 2020
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  19. Alphaherpesvirus Genomics: Past, Present and Future.Current issues in molecular biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicholas RenzetteDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Laura GibsonDepartments of Pediatrics and Medicine, Divisions of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Jeffrey D JensenProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland.
Timothy F KowalikDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: timothy.kowalik@umassmed.edu.

Funding

Congenital CMV and CNS Infection Mechanisms of Protective ImmunityR01AI089956 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI William Jarvis Britt · 2011 to 2026
$7.7M
CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)R01HD061959 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MUSSI-PINHATA, MARISA MARCIA · 2011 to 2023
$5.9M
NIAID NIH HHS R01 AI089956NICHD NIH HHS R01 HD061959NICHD NIH HHS R01HD061959
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

Indexed as

Evolution, MolecularGenetic VariationCytomegalovirusCytomegalovirus InfectionsHumansSpatio-Temporal Analysis

Identifiers

PMID25154343
PMCPMC4195796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.