ArticlePloS one2014
Physical disability, anxiety and depression in people with MS: an internet-based survey via the UK MS Register.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Risk of requiring a walking aid after 6.5 years of ocrelizumab treatment in patients with relapsing multiple sclerosis: Data from the OPERA I and OPERA II trials.European journal of neurology · 2022Trial
- Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry.European journal of neurology · 2022Trial
- Patients Undergoing Substance Abuse Treatment and Receiving Financial Assistance for a Physical Disability Respond Well to Contingency Management Treatment.Journal of substance abuse treatment · 2015Trial
- Correlates of Work-Related Disability Among Injured Garment Workers in Bangladesh: A Cross-Sectional Investigation.Health science reports · 2026Article
- Depression among individuals with disabilities: a community-based cross-sectional study in Nepal.BMJ open · 2025Article
- Associations between social determinants of health and mental health disorders among U.S. population: a cross-sectional study.Epidemiology and psychiatric sciences · 2025Article
- Prevalence and factors affecting anxiety and depression among adult people with physical disabilities in Saudi Arabia: a cross-sectional study.Frontiers in psychology · 2025Article
- Mental health of persons with disabilities during the COVID-19 pandemic in Bangladesh.PloS one · 2025Article
- Cognitive and Metacognitive Determinants of Psychopathology in Individuals with Physical Disabilities: A Comparative Study with a Healthy Control Group.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025Article
- Leveraging Emerging Technologies to Expand Accessibility and Improve Precision in Rehabilitation and Exercise for People with Disabilities.International journal of environmental research and public health · 2024Review
- Wellbeing measurement among adults with Charcot-Marie-Tooth disease.Health care transitions · 2024Article
- Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience.Journal of clinical psychology in medical settings · 2022Article
- Delayed educational services during Covid-19 and their relationships with the mental health of individuals with disabilities.Journal of community psychology · 2022Article
- The contribution of self-disclosure to the prediction of mood symptoms in patients with multiple sclerosis.Current journal of neurology · 2021Article
- Effects of Exercise Programs on Anxiety in Individuals with Disabilities: A Systematic Review with a Meta-Analysis.Healthcare (Basel, Switzerland) · 2021Review
- Content Validity of an Integrated Yoga Module for Practice During Remission in Relapsing-Remitting Multiple Sclerosis Patients.Annals of neurosciences · 2021Article
- C-Reactive Protein Levels and Gadolinium-Enhancing Lesions Are Associated With the Degree of Depressive Symptoms in Newly Diagnosed Multiple Sclerosis.Frontiers in neurology · 2021Article
- Psychiatric disorders in multiple sclerosis.Journal of neurology · 2021Review
- Article
- Observational
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPeople with Multiple Sclerosis are known to have a relatively high prevalence of both anxiety and depression. Studies of the relationship between physical disability and mental health in people with MS have reported mixed results, showing the need for further work.
methodsBetween May 2011 and April 2012, 4516 people completed the MSIS-29 (v.1) and HADS scales via the dedicated internet site of the UK MS Register within a 7 day time window. These responses were linked with basic demographic and descriptive data and analysed in SPSS (v.20).
resultsThe proportions of people experiencing anxiety or depression increased with physical disability such that 38.0% of respondents with low, and 66.7% with high disability reported at least mild anxiety, and 17.1% of people with low, and 71.7% with high disability experienced at least mild depression. The multiple regression model explained 18.4% of the variance in anxiety with MSIS-29-PHYS score being the strongest predictor of anxiety. The model for depression explained 37.8% of the variance with MSIS-29-PHYS score being the strongest predictor. Some of the other variables included showed negative associations with anxiety and depression, indicating that the influence of physical disability on mental wellbeing could be underestimated.
conclusionsThis study indicates that there is a positive relationship between physical disability and anxiety and depression, that physical disability impacts on anxiety and depression to differing extents, and that the effects vary with gender, age, disease course and disease duration. We have shown that physical disability is a predictor of anxiety and depression, and that other factors may mask the extent of this effect. Whether the causes of anxiety and depression are reactive, organic or a combination, it is essential that mental wellbeing is given due attention in caring for people with MS so that all their health needs can be met.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.