ArticlePloS one2014
Plasma brain-derived neurotrophic factor and reverse dipping pattern of nocturnal blood pressure in patients with cardiovascular risk factors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Association of Heart Rate Variability and NeuroCognitive Performance Among Metabolically Healthy Obese Adults: Cardio-psychological Based Approach.Annals of neurosciences · 2026Article
- Associations of sleep disorders and autonomic dysfunction with cardio-renal function.Sleep & breathing = Schlaf & Atmung · 2024Review
- Sleep Apnea and Physical Movement During Sleep, But Not Sleep Duration, Are Independently Associated With Progression of Left Ventricular Diastolic Dysfunction: Prospective Hyogo Sleep Cardio-Autonomic Atherosclerosis Cohort Study.Journal of the American Heart Association · 2022Article
- Xanthine oxidoreductase activity is correlated with hepatic steatosis.Scientific reports · 2022Article
- Sleep quality, autonomic dysfunction and renal function in diabetic patients with pre-CKD phase.Scientific reports · 2021Article
- Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study.Metabolism open · 2020Article
- Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study.Metabolism open · 2020Article
- Is obstructive sleep apnoea the most important determinant of reverse dipping? Hypothesis and evidence.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus.Journal of clinical & translational endocrinology · 2019Article
- Sleep, Autonomic Nervous Function and Atherosclerosis.International journal of molecular sciences · 2019Review
- Article
- The deadly line linking sympathetic overdrive, dipping status and vascular risk: critical appraisal and therapeutic implications.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Relationship between blood pressure reverse dipping and type 2 diabetes in hypertensive patients.Scientific reports · 2016Article
- Article
- Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study.Cardiovascular diabetology · 2015Article
- An Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions.Nursing researchReview
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextBasic studies have shown that brain-derived neurotrophic factor (BDNF) has critical roles in the survival, growth, maintenance, and death of central and peripheral neurons, while it is also involved in regulation of the autonomic nervous system. Furthermore, recent clinical studies have suggested potential role of plasma BDNF in the circulatory system.
objectiveWe investigated the mutual relationships among plasma BDNF, patterns of nocturnal blood pressure changes (dippers, non-dippers, extra-dippers, and reverse-dippers), and cardiac autonomic function as determined by heart rate variability (HRV).
designThis was a cross-sectional study of patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) Study from October 2010 to November 2012. PATIENTS: Two-hundred fifty patients with 1 or more cardiovascular risk factor(s) (obesity, smoking, presence of cardiovascular event history, hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease) were enrolled.
resultsPlasma BDNF levels (natural logarithm transformed) were significantly (p = 0.001) lower in reverse-dipper patients (7.18±0.69 pg/ml, mean ± SD, n = 36) as compared to dippers (7.86±0.86 pg/ml, n = 100). Multiple logistic regression analysis showed that BDNF (odds ratios: 0.417, 95% confidence interval: 0.228-0.762, P = 0.004) was the sole factor significantly and independently associated with the reverse-dippers as compared with dippers. Furthermore, plasma BDNF level was significantly and positively correlated with the time-domain (SDNN, SDANN5, CVRR) and frequency-domain (LF) of HRV parameters. Finally, multiple logistic regression analyses showed that the relationship between plasma BDNF and the reverse-dippers was weakened, yet remained significant or borderline significant even after adjusting for HRV parameters.
conclusionsLow plasma BDNF was independently associated with patients showing a reverse-dipper pattern of nocturnal blood pressure, in which an imbalance of cardiac autonomic function may be partly involved.
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