Evidence map›Paper›PMID 25153779›Full record

ArticleActa biomaterialia2014

Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells.

Heemin Kang, Yu-Ru V Shih, Yongsung Hwang, Cai Wen, Vikram Rao, Timothy Seo, Shyni Varghese

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  10. Static and Dynamic Biomaterial Engineering for Cell Modulation.Nanomaterials (Basel, Switzerland) · 2022
    Review
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  19. In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.Advanced materials (Deerfield Beach, Fla.) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Heemin KangDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA.
Yu-Ru V ShihDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Yongsung HwangDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Cai WenDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018, China.
Vikram RaoDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Timothy SeoDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Shyni VargheseDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: svarghese@ucsd.edu.
University of California, San Diego · US

Funding

Diversity Supplement -"Bioinspired Synthetic Grafts for Bone Regeneration"R01AR063184 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARGHESE, SHYNI · 2013 to 2017
$1.7M
NIAMS NIH HHS 1 R01 AR063184-01A1NIAMS NIH HHS R01 AR063184
6 · The paper itself

Abstract

Human induced pluripotent stem cells (hiPSC) are a promising cell source with pluripotency and self-renewal properties. Design of simple and robust biomaterials with an innate ability to induce lineage-specificity of hiPSC is desirable to realize their application in regenerative medicine. In this study, the potential of biomaterials containing calcium phosphate minerals to induce osteogenic differentiation of hiPSC was investigated. hiPSC cultured using mineralized gelatin methacrylate-based matrices underwent osteogenic differentiation ex vivo, in both two-dimensional and three-dimensional cultures, in growth medium devoid of any osteogenic-inducing chemical components or growth factors. The findings that osteogenic differentiation of hiPSC can be achieved through biomaterial-based cues alone present new avenues for personalized regenerative medicine. Such biomaterials that could not only act as structural scaffolds, but could also provide tissue-specific functions such as directing stem cell differentiation commitment, have great potential in bone tissue engineering.

Indexed as

Materials TestingBiomimetic MaterialsBone SubstitutesCalcification, PhysiologicCalcium PhosphatesCell DifferentiationCell ProliferationCells, CulturedCell SurvivalExtracellular MatrixGelatinHumansMethacrylatesOsteoblastsOsteogenesisPluripotent Stem CellsBone Substitutescalcium phosphateCalcium PhosphatesGelatinMethacrylatesBone tissue engineeringCalcium phosphateGelatin methacrylateHuman induced pluripotent stem cellsOsteogenic differentiation

Identifiers

PMID25153779
PMCPMC4252258
OpenAlexW2018593634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.