ArticleGenomics, proteomics & bioinformatics2014
FunMod: a Cytoscape plugin for identifying functional modules in undirected protein-protein networks.
Article in Genomics, proteomics & bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A multiple network-based bioinformatics pipeline for the study of molecular mechanisms in oncological diseases for personalized medicine.Briefings in bioinformatics · 2021Article
- Computational systems biology approaches for Parkinson's disease.Cell and tissue research · 2018Review
- Global Gene Expression Analysis Reveals Crosstalk between Response Mechanisms to Cold and Drought Stresses in Cassava Seedlings.Frontiers in plant science · 2017Article
- NET-GE: a novel NETwork-based Gene Enrichment for detecting biological processes associated to Mendelian diseases.BMC genomics · 2015Article
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Authors and funding
4 authors.
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Abstract
The characterization of the interacting behaviors of complex biological systems is a primary objective in protein-protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected protein-protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in diseases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.
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