Evidence map›Paper›PMID 25153326›Full record

ArticlePloS one2014

Metallization and biopatterning on ultra-flexible substrates via dextran sacrificial layers.

Peter Tseng, Ivan Pushkarsky, Dino Di Carlo

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Obesity increases airway smooth muscle responses to contractile agonists.American journal of physiology. Lung cellular and molecular physiology · 2018
    Article
  6. Article
  7. Review
  8. GαBritish journal of pharmacology · 2017
    Article
  9. Article
  10. Article
  11. Flexible and stretchable micromagnet arrays for tunable biointerfacing.Advanced materials (Deerfield Beach, Fla.) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Peter TsengDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America.
Ivan PushkarskyDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America.
Dino Di CarloDepartment of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America.
University of California, Los Angeles · US

Funding

Engineering the Intracellular Micro- and NanoenvironmentDP2OD007113 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DI CARLO, DINO · 2010 to 2010
$2.3M
NIH HHS 1DP2OD007113NIH HHS DP2 OD007113
6 · The paper itself

Abstract

Micro-patterning tools adopted from the semiconductor industry have mostly been optimized to pattern features onto rigid silicon and glass substrates, however, recently the need to pattern on soft substrates has been identified in simulating cellular environments or developing flexible biosensors. We present a simple method of introducing a variety of patterned materials and structures into ultra-flexible polydimethylsiloxane (PDMS) layers (elastic moduli down to 3 kPa) utilizing water-soluble dextran sacrificial thin films. Dextran films provided a stable template for photolithography, metal deposition, particle adsorption, and protein stamping. These materials and structures (including dextran itself) were then readily transferrable to an elastomer surface following PDMS (10 to 70∶1 base to crosslinker ratios) curing over the patterned dextran layer and after sacrificial etch of the dextran in water. We demonstrate that this simple and straightforward approach can controllably manipulate surface wetting and protein adsorption characteristics of PDMS, covalently link protein patterns for stable cell patterning, generate composite structures of epoxy or particles for study of cell mechanical response, and stably integrate certain metals with use of vinyl molecular adhesives. This method is compatible over the complete moduli range of PDMS, and potentially generalizable over a host of additional micro- and nano-structures and materials.

Indexed as

AdhesivesAdsorptionBiosensing TechniquesDextransDimethylpolysiloxanesMaterials TestingMetalsNanotechnologySemiconductorsSurface PropertiesWaterWettabilityAdhesivesbaysilonDextransDimethylpolysiloxanesMetalsWater

Identifiers

PMID25153326
PMCPMC4143360
OpenAlexW2042269628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.