SynthesisPloS one2014
Sedentary behavior and incident cancer: a meta-analysis of prospective studies.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 7 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.JNCI cancer spectrum · 2025Pooled it
- Environmental risk factors, protective factors and lifestyles for lung cancer: an umbrella review.Frontiers in public health · 2025Pooled it
- National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study.Journal of global health · 2023Pooled it
- Association between domain-specific sedentary behaviour and endometrial cancer: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- The Effectiveness of Interventions to Reduce Sedentary Time in Different Target Groups and Settings in Germany: Systematic Review, Meta-Analysis and Recommendations on Interventions.International journal of environmental research and public health · 2022Pooled it
- Sedentary behavior and cancer-an umbrella review and meta-analysis.European journal of epidemiology · 2022Pooled it
- Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis.European journal of epidemiology · 2021Pooled it
- Effectiveness of an intervention for reducing sitting time and improving health in office workers: three arm cluster randomised controlled trial.BMJ (Clinical research ed.) · 2022Trial
- Modelling the potential health and economic benefits of reducing population sitting time in Australia.The international journal of behavioral nutrition and physical activity · 2022Trial
- A Cost and Cost-Benefit Analysis of the Stand More AT Work (SMArT Work) Intervention.International journal of environmental research and public health · 2020Trial
- Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial.BMJ (Clinical research ed.) · 2018Trial
- A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers: study protocol.BMC public health · 2018Trial
- Stand More AT Work (SMArT Work): using the behaviour change wheel to develop an intervention to reduce sitting time in the workplace.BMC public health · 2018Trial
- Trial
- Providing NHS staff with height-adjustable workstations and behaviour change strategies to reduce workplace sitting time: protocol for the Stand More AT (SMArT) Work cluster randomised controlled trial.BMC public health · 2015Trial
- The association of sedentary time and physical activity with colorectal adenoma: A colonoscopy-based study.Journal of the Chinese Medical Association : JCMA · 2026Article
- The economic costs of excessive sedentary behaviour in Japan.Journal of public health (Oxford, England) · 2026Article
- Mortality trends of endometrial cancer in the female adult population of the United States from 1999 to 2020.Frontiers in oncology · 2026Article
- Association of lifestyle factors with breast cancer incidence: An overview of systematic reviews.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Cancer Risk Perceptions in South Australia: A Descriptive Analysis of a Population Survey.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundSedentary behavior is ubiquitous in modern adults' daily lives and it has been suggested to be associated with incident cancer. However, the results have been inconsistent. In this study, we performed a systematic review and meta-analysis of prospective cohort studies to clarify the association between sedentary behavior and incident cancer.
methodPubMed and Embase databases were searched up to March 2014. All prospective cohort studies on the association between sedentary behavior and incident cancer were included. The summary relative risks (RRs) with 95% confidence intervals (CIs) were estimated using random effect model.
resultsA total of 17 prospective studies from 14 articles, including a total of 857,581 participants and 18,553 cases, were included in the analysis for sedentary behavior and risk of incident cancer. The overall meta-analysis suggested that sedentary behavior increased risk of cancer (RR = 1.20, 95%CI = 1.12-1.28), with no evidence of heterogeneity between studies (I(2) = 7.3%, P = 0.368). Subgroup analyses demonstrated that there were statistical associations between sedentary behavior and some cancer types (endometrial cancer: RR = 1.28, 95% CI = 1.08-1.53; colorectal cancer: RR = 1.30, 95%CI = 1.12-1.49; breast cancer: RR = 1.17, 95%CI = 1.03-1.33; lung cancer: RR = 1.27, 95%CI = 1.06-1.52). However, there was no association of sedentary behavior with ovarian cancer (RR = 1.26, 95%CI = 0.87-1.82), renal cell carcinoma (RR = 1.11, 95%CI = 0.87-1.41) or non-Hodgkin lymphoid neoplasms (RR = 1.09, 95%CI = 0.82-1.43).
conclusionThe present meta-analysis suggested that prolonged sedentary behavior was independently associated with an increased risk of incident endometrial, colorectal, breast, and lung cancers, but not with ovarian cancer, renal cell carcinoma or non-Hodgkin lymphoid neoplasms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.