Evidence map›Paper›PMID 25153300›Full record

ReviewJournal of occupational and environmental medicine2014

Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence.

Thomas H Connor, Christina C Lawson, Martha Polovich, Melissa A McDiarmid

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of occupational and environmental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 6 pooled it
34.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 169 citations in OpenAlex.

  1. Pooled it
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  3. Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data.International journal of environmental research and public health · 2022
    Pooled it
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  5. Safe handling of oral antineoplastic medications: Focus on targeted therapeutics in the home setting.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2017
    Pooled it
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thomas H ConnorFrom THC-Research Biologist, Division of Applied Research and Technology (Dr Connor) and CCL-Lead Health Scientist, Division of Surveillance Hazard Evaluations & Field Studies (Dr Lawson), National Institute for Occupational Safety and Health, Cincinnati, Ohio; Clinical Associate Professor, Byrdine F. Lewis School of Nursing and Health Professions (Dr Polovich), Georgia State University, Atlanta; and Division of Occupational and Environmental Medicine (Dr McDiarmid), University of Maryland School of Medicine, Baltimore.
Christina C Lawson
Martha Polovich
Melissa A McDiarmid
University of Baltimore · USAID Atlanta · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectivesAntineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs.

methodsA structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed.

resultsAlthough effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time to pregnancy also suggested an increased risk for subfertility.

conclusionsAntineoplastic drugs are highly toxic in patients receiving treatment, and adverse reproductive effects have been well documented in these patients. Health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered.

Indexed as

Health PersonnelReproductive HealthAntineoplastic AgentsFemaleHealth FacilitiesHumansMaleOccupational ExposureReproductionAntineoplastic Agents

Identifiers

PMID25153300
PMCPMC4569003
OpenAlexW2129363786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.