Evidence map›Paper›PMID 25152865›Full record

ArticleGenomics data2014

Changes in nucleosome occupancy occur in a chromosome specific manner.

Brittany S Sexton, Brooke R Druliner, Denis Avey, Fanxiu Zhu, Jonathan H Dennis

Abstract read
In one paragraph

Article in Genomics data, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brittany S SextonDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
Brooke R DrulinerDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
Denis AveyDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
Fanxiu ZhuDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
Jonathan H DennisDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.

Funding

Role of KSHV ORF45 in Viral Immune Evasion &ReplicationR01DE016680 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI ZHU, FANXIU · 2005 to 2015
$2.5M
Chromatin structural changes linking drugs of abuse with HIV reactivationR01DA033775 · NIDA · FLORIDA STATE UNIVERSITY · PI DENNIS, JONATHAN H · 2012 to 2016
$1.8M
NIDA NIH HHS R01 DA033775NIDCR NIH HHS R01 DE016680
6 · The paper itself

Abstract

In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core. Nuclear processes in eukaryotes are impacted by whether regulatory DNA is occupied by nucleosomes. We used microarrays to measure nucleosome occupancy in human cells post Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation at hundreds of immunity-related loci. The detailed analysis of these technologies can be found in recent publications from our lab (Druliner et al., 2013; Sexton et al., 2014). We found that nucleosome redistributions displayed chromosome specific nucleosome occupancy. This resource can be used to map nucleosome distributions in a variety of biological contexts.

Identifiers

PMID25152865
PMCPMC4138544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.