ArticleEvidence-based complementary and alternative medicine : eCAM2014
Antimutagenicity of Methanolic Extracts from Anemopsis californica in Relation to Their Antioxidant Activity.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- A perspective review on factors that influence mutagenicity in medicinal plants and their health implications.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- A First Look at the Inhibitory Potential ofToxins · 2022Article
- Article
- Antimutagenic, Cytoprotective and Antioxidant Properties ofMolecules (Basel, Switzerland) · 2021Article
- A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential ofSaudi journal of biological sciences · 2019Article
- Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- Delineation of attenuation of oxidative stress and mutagenic stress by Murraya exotica L. leaves.SpringerPlus · 2016Article
- Anti-Inflammatory Activity and Changes in Antioxidant Properties of Leaf and Stem Extracts from Vitex mollis Kunth during In Vitro Digestion.Evidence-based complementary and alternative medicine : eCAM · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemopsis californica has been used empirically to treat infectious diseases. However, there are no antimutagenic evaluation reports on this plant. The present study evaluated the antioxidant activity in relation to the mutagenic and antimutagenic activity properties of leaf (LME) and stem (SME) methanolic extracts of A. californica collected in the central Mexican state of Querétaro. Antioxidant properties and total phenols of extracts were evaluated using DPPH (1,1-diphenyl-2-picrylhydrazyl) and Folin-Ciocalteu methods, respectively. Mutagenicity was evaluated using the Ames test employing Salmonella enterica serovar Typhimurium strains (TA98, TA100, and TA102), with and without an aroclor 1254 (S9 mixture). Antimutagenesis was performed against mutations induced on the Ames test with MNNG, 2AA, or 4NQO. SME presented the highest antioxidant capacity and total phenolic content. None of the extracts exhibited mutagenicity in the Ames test. The extracts produced a significant reduction in 2AA-induced mutations in S. typhimurium TA98. In both extracts, mutagenesis induced by 4NQO or methyl-N'-nitro-N-nitrosoguanidine (MNNG) was reduced only if the exposure of strains was <10 μg/Petri dish. A. californca antioxidant properties and its capacity to reduce point mutations render it suitable to enhance medical cancer treatments. The significant effect against antimutagenic 2AA suggests that their consumption would provide protection against carcinogenic polycyclic aromatic compounds.
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Registered trials
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