ArticleFrontiers in genetics2014
Extension of the generalized disequilibrium test to polytomous phenotypes and two-locus models.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Polyunphased: an extension to polytomous outcomes of the Unphased package for family-based genetic association analysis.Statistical applications in genetics and molecular biology · 2017Article
- On the validity of within-nuclear-family genetic association analysis in samples of extended families.Statistical applications in genetics and molecular biology · 2015Article
- Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions.Frontiers in genetics · 2015Article
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5 authors.
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Abstract
we extend the usual logistic model between a dichotomous phenotype and an allele count in two waysa polytomous phenotype with K > 2 levels, and modeling of allele counts at two unlinked marker loci. Inference is based on within-family information to guard against potential bias due to population genetic structure. Score tests of the model coefficients taking into account the correlation between relatives in entire pedigrees are derived as an extension of the Generalized Disequilibrium Test (GDT). Simulations confirm that the tests have the expected statistical properties, and that their power exceeds that of the GDT under a favorable scenario. The score tests are illustrated with candidate genetic markers, a major psychosis phenotype and a cognitive endophenotype in large kindreds from Eastern Quebec.
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