ReviewFrontiers in plant science2014
Recombinant production of plant lectins in microbial systems for biomedical application - the frutalin case study.
Review in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- EGFR and p38Pharmaceuticals (Basel, Switzerland) · 2023Article
- Fermentation Strategies for Production of Pharmaceutical Terpenoids in Engineered Yeast.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Application of Lectin Microarrays for Biomarker Discovery.ChemistryOpen · 2020Review
- Induction of Recombinant Lectin Expression by an Artificially Constructed Tandem Repeat Structure: A Case Study UsingBiomolecules · 2018Article
- Expression of Lectins in Heterologous Systems.International journal of molecular sciences · 2018Review
- Identification of Banana Lectin Isoforms and Differential Acetylation Through Mass Spectrometry Approaches.The protein journal · 2018Article
- Functional Expression and Characterization of the Recombinant N-Acetyl-Glucosamine/N-Acetyl-Galactosamine-Specific Marine Algal Lectin BPL3.Marine drugs · 2018Article
- Functional characterization of chitin-binding lectin from Solanum integrifolium containing anti-fungal and insecticidal activities.BMC plant biology · 2018Article
- The purplish bifurcate mussel Mytilisepta virgata gene expression atlas reveals a remarkable tissue functional specialization.BMC genomics · 2017Article
- Encapsulation into Stealth Liposomes Enhances the Antitumor Action of RecombinantFrontiers in microbiology · 2016Article
- Functional recombinants designed from a fetuin/asialofetuin-specific marine algal lectin, rhodobindin.Marine drugs · 2015Article
- Plant Glycobiology-a diverse world of lectins, glycoproteins, glycolipids and glycans.Frontiers in plant science · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frutalin is a homotetrameric partly glycosylated α-D-galactose-binding lectin of biomedical interest from Artocarpus incisa (breadfruit) seeds, belonging to the jacalin-related lectins family. As other plant lectins, frutalin is a heterogeneous mixture of several isoforms possibly with distinct biological activities. The main problem of using such lectins as biomedical tools is that "batch-to-batch" variation in isoforms content may lead to inconstant results. The production of lectins by recombinant means has the advantage of obtaining high amounts of proteins with defined amino-acid sequences and more precise properties. In this mini review, we provide the strategies followed to produce two different forms of frutalin in two different microbial systems: Escherichia coli and Pichia pastoris. The processing and functional properties of the recombinant frutalin obtained from these hosts are compared to those of frutalin extracted from breadfruit. Emphasis is given particularly to recombinant frutalin produced in P. pastoris, which showed a remarkable capacity as biomarker of human prostate cancer and as apoptosis-inducer of cancer cells. Recombinant frutalin production opens perspectives for its development as a new tool in human medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.